Effect of Oxidative Stress on the Estrogen-NOS-NO-KCa Channel Pathway in Uteroplacental Dysfunction: Its Implication in Pregnancy Complications
Joint Authors
Hu, Xiang-Qun
Song, Rui
Zhang, Lubo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-10
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
During pregnancy, the adaptive changes in uterine circulation and the formation of the placenta are essential for the growth of the fetus and the well-being of the mother.
The steroid hormone estrogen plays a pivotal role in this adaptive process.
An insufficient blood supply to the placenta due to uteroplacental dysfunction has been associated with pregnancy complications including preeclampsia and intrauterine fetal growth restriction (IUGR).
Oxidative stress is caused by an imbalance between free radical formation and antioxidant defense.
Pregnancy itself presents a mild oxidative stress, which is exaggerated in pregnancy complications.
Increasing evidence indicates that oxidative stress plays an important role in the maladaptation of uteroplacental circulation partly by impairing estrogen signaling pathways.
This review is aimed at providing both an overview of our current understanding of regulation of the estrogen-NOS-NO-KCa pathway by reactive oxygen species (ROS) in uteroplacental tissues and a link between oxidative stress and uteroplacental dysfunction in pregnancy complications.
A better understanding of the mechanisms will facilitate the development of novel and effective therapeutic interventions.
American Psychological Association (APA)
Hu, Xiang-Qun& Song, Rui& Zhang, Lubo. 2019. Effect of Oxidative Stress on the Estrogen-NOS-NO-KCa Channel Pathway in Uteroplacental Dysfunction: Its Implication in Pregnancy Complications. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1206197
Modern Language Association (MLA)
Hu, Xiang-Qun…[et al.]. Effect of Oxidative Stress on the Estrogen-NOS-NO-KCa Channel Pathway in Uteroplacental Dysfunction: Its Implication in Pregnancy Complications. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-19.
https://search.emarefa.net/detail/BIM-1206197
American Medical Association (AMA)
Hu, Xiang-Qun& Song, Rui& Zhang, Lubo. Effect of Oxidative Stress on the Estrogen-NOS-NO-KCa Channel Pathway in Uteroplacental Dysfunction: Its Implication in Pregnancy Complications. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1206197
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206197