Enhancement of Executive Functions but Not Memory by Multidomain Group Cognitive Training in Patients with Parkinson’s Disease and Mild Cognitive Impairment: A Multicenter Randomized Controlled Trial

Joint Authors

Schulte, Claudia
Kalbe, Elke
Folkerts, Ann-Kristin
Ophey, Anja
Eggers, Carsten
Elben, Saskia
Dimenshteyn, Karina
Sulzer, Patricia
Schmidt, Nele
Schlenstedt, Christian
Berg, Daniela
Witt, Karsten
Wojtecki, Lars
Liepelt-Scarfone, Inga

Source

Parkinson’s Disease

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-11-30

Country of Publication

Egypt

No. of Pages

15

Main Subjects

Diseases
Medicine

Abstract EN

Background.

Meta-analyses have demonstrated cognitive training (CT) benefits in Parkinson’s disease (PD) patients.

However, the patients’ cognitive status has only rarely been based on established criteria.

Also, prediction analyses of CT success have only sparsely been conducted.

Objective.

To determine CT effects in PD patients with mild cognitive impairment (PD-MCI) on cognitive and noncognitive outcomes compared to an active control group (CG) and to analyze CT success predictors.

Methods.

Sixty-four PD-MCI patients (age: 67.61 ± 7.70; UPDRS-III: 26.58 ± 13.54; MoCA: 24.47 ± 2.78) were randomized to either a CT group or a low-intensity physical activity CG for six weeks (twice weekly, 90 minutes).

Outcomes were assessed before and after training.

MANOVAs with follow-up ANOVAs and multiple regression analyses were computed.

Results.

Both interventions were highly feasible (participation, motivation, and evaluation); the overall dropout rate was 4.7%.

Time × group interaction effects favoring CT were observed for phonemic fluency as a specific executive test (p=0.018, ηp2=0.092) and a statistical trend for overall executive functions (p=0.095, ηp2=0.132).

A statistical trend for a time × group interaction effect favoring CG was shown for the digit span backward as a working memory test (p=0.098, ηp2=0.043).

Regression analyses revealed cognitive baseline levels, education, levodopa equivalent daily dose, motor scores, and ApoE status as significant predictors for CT success.

Conclusions.

CT is a safe and feasible therapy option in PD-MCI, yielding executive functions improvement.

Data indicate that vulnerable individuals may show the largest cognitive gains.

Longitudinal studies are required to determine whether CT may also attenuate cognitive decline in the long term.

This trial is registered with DRKS00010186.

American Psychological Association (APA)

Kalbe, Elke& Folkerts, Ann-Kristin& Ophey, Anja& Eggers, Carsten& Elben, Saskia& Dimenshteyn, Karina…[et al.]. 2020. Enhancement of Executive Functions but Not Memory by Multidomain Group Cognitive Training in Patients with Parkinson’s Disease and Mild Cognitive Impairment: A Multicenter Randomized Controlled Trial. Parkinson’s Disease،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1206445

Modern Language Association (MLA)

Kalbe, Elke…[et al.]. Enhancement of Executive Functions but Not Memory by Multidomain Group Cognitive Training in Patients with Parkinson’s Disease and Mild Cognitive Impairment: A Multicenter Randomized Controlled Trial. Parkinson’s Disease No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1206445

American Medical Association (AMA)

Kalbe, Elke& Folkerts, Ann-Kristin& Ophey, Anja& Eggers, Carsten& Elben, Saskia& Dimenshteyn, Karina…[et al.]. Enhancement of Executive Functions but Not Memory by Multidomain Group Cognitive Training in Patients with Parkinson’s Disease and Mild Cognitive Impairment: A Multicenter Randomized Controlled Trial. Parkinson’s Disease. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1206445

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1206445