Risk of Dementia in Patients with Depression or Parkinson’s Disease: A Retrospective Cohort Study
Joint Authors
Fang, Ting-Chun
Wu, Yu-Hsuan
Chen, Yi-Huei
Lin, Ching-Heng
Chang, Ming-Hong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
This study aimed to clarify whether Parkinson’s disease (PD) and depression were independent risk factors or with synergic effects in dementia.
Methods.
Newly diagnosed PD (n = 1213) patients and control subjects (n = 4852) were selected from the Taiwan National Health Insurance Research Database from January 2001 through December 2008.
Follow-up ended in 2011 with an outcome of dementia occurring or not.
This cohort was divided into controls with or without depression, PD only, and PD with depression.
The incident rate of dementia and hazard ratio (HR) using Cox’s regression analysis were calculated for each group.
Results.
When compared with controls without depression as HR 1.00, the adjusted HR for dementia was 3.29 (p<0.001) in the PD only group, 2.77 (p<0.001) in the PD with depression group, and 1.55 (p=0.024) in the depression only group.
The incident rate of dementia was 29.2 (per 1000 person-years) in the PD only group and 13.2 in the PD with depression group.
The effect of PD on dementia in the depression group produced a HR of 0.97 (p=0.905).
Conclusions.
Parkinson’s disease served as a risk factor for dementia.
By comparison, depression was not a risk factor for dementia in PD patients, although it did act as a risk factor for dementia.
American Psychological Association (APA)
Fang, Ting-Chun& Wu, Yu-Hsuan& Chen, Yi-Huei& Lin, Ching-Heng& Chang, Ming-Hong. 2020. Risk of Dementia in Patients with Depression or Parkinson’s Disease: A Retrospective Cohort Study. Parkinson’s Disease،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1206508
Modern Language Association (MLA)
Fang, Ting-Chun…[et al.]. Risk of Dementia in Patients with Depression or Parkinson’s Disease: A Retrospective Cohort Study. Parkinson’s Disease No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1206508
American Medical Association (AMA)
Fang, Ting-Chun& Wu, Yu-Hsuan& Chen, Yi-Huei& Lin, Ching-Heng& Chang, Ming-Hong. Risk of Dementia in Patients with Depression or Parkinson’s Disease: A Retrospective Cohort Study. Parkinson’s Disease. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1206508
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206508