Crocetin Alleviates Inflammation in MPTP-Induced Parkinson’s Disease Models through Improving Mitochondrial Functions
Joint Authors
Dong, Na
Dong, Zhong
Chen, Ying
Gu, Xiaosu
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Parkinson’s disease (PD) is the second most common neurodegenerative disease.
Crocetin, derived from saffron, exerts multiple pharmacological properties, such as anti-inflammatory, antioxidant, antifatigue, and anticancer effects.
However, the effect of crocetin on PD remains unclear.
In this study, we designed experiments to investigate the effect of crocetin against MPTP-induced PD models and the underlying mechanisms.
Our results showed that crocetin treatment attenuates MPTP-induced motor deficits and protects dopaminergic neurons.
Both in vivo and in vitro experiments demonstrated that crocetin treatment decreased the expression of inflammatory associated genes and inflammatory cytokines.
Furthermore, crocetin treatment protected mitochondrial functions against MPP+ induced damage by regulating the mPTP (mitochondrial permeability transition pore) viability in the interaction of ANT (adenine nucleotide translocase) and Cyp D (Cyclophilin D) dependent manner.
Therefore, our results demonstrate that crocetin has therapeutic potential in Parkinson’s disease.
American Psychological Association (APA)
Dong, Na& Dong, Zhong& Chen, Ying& Gu, Xiaosu. 2020. Crocetin Alleviates Inflammation in MPTP-Induced Parkinson’s Disease Models through Improving Mitochondrial Functions. Parkinson’s Disease،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1206545
Modern Language Association (MLA)
Dong, Na…[et al.]. Crocetin Alleviates Inflammation in MPTP-Induced Parkinson’s Disease Models through Improving Mitochondrial Functions. Parkinson’s Disease No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1206545
American Medical Association (AMA)
Dong, Na& Dong, Zhong& Chen, Ying& Gu, Xiaosu. Crocetin Alleviates Inflammation in MPTP-Induced Parkinson’s Disease Models through Improving Mitochondrial Functions. Parkinson’s Disease. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1206545
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206545