The Model of PPARγ-Downregulated Signaling in Psoriasis
Joint Authors
Sobolev, Vladimir
Nesterova, Anastasia
Dvoriankova, Evgenia
Piruzyan, Anastas
Mildzikhova, Dzerassa
Korsunskaya, Irina
Svitich, Oxana
Soboleva, Anna
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Interactions of genes in intersecting signaling pathways, as well as environmental influences, are required for the development of psoriasis.
Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor and transcription factor which inhibits the expression of many proinflammatory genes.
We tested the hypothesis that low levels of PPARγ expression promote the development of psoriatic lesions.
We combined experimental results and network functional analysis to reconstruct the model of PPARγ-downregulated signaling in psoriasis.
We hypothesize that the expression of IL17, STAT3, FOXP3, and RORC and FOSL1 genes in psoriatic skin is correlated with the level of PPARγ expression, and they belong to the same signaling pathway that regulates the development of psoriasis lesion.
American Psychological Association (APA)
Sobolev, Vladimir& Nesterova, Anastasia& Soboleva, Anna& Dvoriankova, Evgenia& Piruzyan, Anastas& Mildzikhova, Dzerassa…[et al.]. 2020. The Model of PPARγ-Downregulated Signaling in Psoriasis. PPAR Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1206626
Modern Language Association (MLA)
Sobolev, Vladimir…[et al.]. The Model of PPARγ-Downregulated Signaling in Psoriasis. PPAR Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1206626
American Medical Association (AMA)
Sobolev, Vladimir& Nesterova, Anastasia& Soboleva, Anna& Dvoriankova, Evgenia& Piruzyan, Anastas& Mildzikhova, Dzerassa…[et al.]. The Model of PPARγ-Downregulated Signaling in Psoriasis. PPAR Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1206626
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206626
