Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local Anesthetic

Joint Authors

Park, Jung-Ho
Park, Jae-Hyung
Son, Jo-Young
Lim, Jae-Seong
Park, Jae-Hyeong
Kim, Myeong-Shin
Oh, Jun-suk
Yoon, Hyun-Wu
Ju, Jin-Sook
Ahn, Dong-Kuk

Source

Pain Research and Management

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-11-26

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Diseases

Abstract EN

Mannitol has recently been reported to be effective in enhancing the antinociceptive efficacy of lidocaine.

No single study to date, however, has compared diphenhydramine with and without mannitol for nociceptive processing as an alternative local anesthetic.

In this study, we examined the antinociceptive efficacy enhancements of diphenhydramine when combined with mannitol.

Male Sprague-Dawley rats weighing 230–260 g were used in a hot plate test to evaluate the antinociceptive effects of diphenhydramine.

All chemicals were dissolved in isotonic normal saline and administered subcutaneously into the plantar surface of the right hind paw at 10 min before the hot plate test.

A subcutaneous injection of 0.5% or 1% diphenhydramine produced significant inhibition of the withdrawal latency time compared with the vehicle treatment.

Antinociceptive effects appeared 10 min after the diphenhydramine injections and persisted for over 30 min.

The antinociceptive effects of 1% diphenhydramine were not statistically different from those of 1% lidocaine.

Although a subcutaneous injection of a 0.5 M mannitol solution alone did not affect the withdrawal latency time, 1% diphenhydramine with 0.5 M mannitol significantly enhanced antinociception.

A subcutaneous injection of 1% diphenhydramine with epinephrine (1 : 100,000) solution did not increase the antinociceptive effect of the diphenhydramine.

These results suggest that diphenhydramine with mannitol can be used as an alternative local anesthetic.

American Psychological Association (APA)

Son, Jo-Young& Lim, Jae-Seong& Park, Jae-Hyung& Park, Jae-Hyeong& Kim, Myeong-Shin& Park, Jung-Ho…[et al.]. 2020. Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local Anesthetic. Pain Research and Management،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1207005

Modern Language Association (MLA)

Son, Jo-Young…[et al.]. Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local Anesthetic. Pain Research and Management No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1207005

American Medical Association (AMA)

Son, Jo-Young& Lim, Jae-Seong& Park, Jae-Hyung& Park, Jae-Hyeong& Kim, Myeong-Shin& Park, Jung-Ho…[et al.]. Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local Anesthetic. Pain Research and Management. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1207005

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1207005