Exercise Capacity in Unilateral Diaphragm Paralysis: The Effect of Obesity
Joint Authors
Richman, Paul S.
Yeung, Pomin
Bilfinger, Thomas V.
Yang, Jie
Stringer, William W.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
Healthy patients with unilateral diaphragm paralysis (UDP) are often asymptomatic; those with UDP and comorbidities that increase work of breathing are often dyspneic.
We report the effect of obesity on exercise capacity in UDP patients.
Methods.
All obese and nonobese patients with UDP undergoing cardiopulmonary exercise testing (CPET) during a 32-month period in the exercise laboratory of an academic hospital were compared to a retrospectively identified cohort of obese and nonobese controls without UDP, matched for key features.
CPET used a modified Bruce treadmill protocol with breath-to-breath expired gas analysis.
O2 uptake, minute ventilation, exercise time, and work rate were recorded at peak exercise.
Static pulmonary functions were measured.
Kruskal-Wallis, Wilcoxon rank sum, and Fisher’s exact tests were used to compare continuous and categorical variables, respectively.
Stratified linear regression was used to quantify the effect of UDP and obesity on CPET variables.
Results.
Twenty-two UDP patients and 46 controls were studied.
The BMI of obese and nonobese patients was 33.0±4.2 and 25.8±2.4 kg/m2, respectively.
UDP subjects with obesity, compared to controls with neither condition, showed significantly reduced peak O2 uptake normalized to actual body weight (1.57±0.64 versus 2.01±0.88 L/min), shorter exercise time (5.7±2.0 versus 8.5±2.9 minutes), and lower peak ventilation.
This was not observed in UDP alone or obesity alone.
Peak work rate trended lower in the combined UDP-obesity group.
Conclusion.
Neither UDP nor obesity alone significantly reduced exercise capacity.
Superimposed UDP and obesity interact to create a ventilatory limitation to exercise, with reduced peak-VO2, exercise time, and work rate.
American Psychological Association (APA)
Richman, Paul S.& Yeung, Pomin& Bilfinger, Thomas V.& Yang, Jie& Stringer, William W.. 2019. Exercise Capacity in Unilateral Diaphragm Paralysis: The Effect of Obesity. Pulmonary Medicine،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1207061
Modern Language Association (MLA)
Richman, Paul S.…[et al.]. Exercise Capacity in Unilateral Diaphragm Paralysis: The Effect of Obesity. Pulmonary Medicine No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1207061
American Medical Association (AMA)
Richman, Paul S.& Yeung, Pomin& Bilfinger, Thomas V.& Yang, Jie& Stringer, William W.. Exercise Capacity in Unilateral Diaphragm Paralysis: The Effect of Obesity. Pulmonary Medicine. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1207061
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207061