15-Deoxy-∆-12,14-Prostaglandin J2 (15d-PGJ2)‎, an Endogenous Ligand of PPAR-γ: Function and Mechanism

Abstract EN

15-Deoxy-∆-12,14-prostaglandin J2 (15d-PGJ2), a natural peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, has been explored in some detail over the last 20 years.

By triggering the PPAR-γ signalling pathway, it plays many roles and exerts antitumour, anti-inflammatory, antioxidation, antifibrosis, and antiangiogenesis effects.

Although many synthetic PPAR-γ receptor agonists have been developed, as an endogenous product of PPAR-γ receptors, 15d-PGJ2 has beneficial characteristics including rapid expression and the ability to contribute to a natural defence mechanism.

In this review, we discuss the latest advances in our knowledge of the biological role of 15d-PGJ2 mediated through PPAR-γ.

It is important to understand its structure, synthesis, and functional mechanisms to develop preventive agents and limit the progression of associated diseases.