PPAR-γ Ligand Inhibits Nasopharyngeal Carcinoma Cell Proliferation and Metastasis by Regulating E2F2
Joint Authors
Yang, Ping-Li
Wang, Jia-Shun
Cheng, Xiao-Mei
Chen, Jing-Cai
Zhu, Hui
Li, Xiao-Lan
Cao, Li
Tang, Wei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a nuclear hormone receptor with a key role in lipid metabolism.
Previous studies have identified various roles of PPAR-γ in cell cycle progression, cellular proliferation, and tumor progression.
However, no report has described a role for PPAR-γ in human nasopharyngeal carcinoma (NPC).
Notably, some studies have reported a relationship between PPAR-γ and E2F transcription factor 2 (E2F2), which has been identified as a regulator of cell cycle, apoptosis, and the DNA damage response.
Notably, E2F2 has also been reported to correlate with a poor prognosis in patients with various malignancies.
Methods.
We used immunohistochemical (IHC) and western blot methods to evaluate PPAR-γ and E2F2 expression and function in nonkeratinizing NPC and nasopharyngitis (NPG) tissue samples, as well as western blotting and CCK8 analyses in the NPC cell lines, CNE1 and CNE2.
Results.
We observed lower levels of PPAR-γ expression in nonkeratinizing NPC tissues compared with NPG tissues and determined an association between a low level of PPAR-γ expression with a more advanced tumor stage.
Furthermore, strong E2F2 expression was detected in nonkeratinizing NPC tissues.
We further demonstrated that rosiglitazone, a PPAR-γ agonist, reduced E2F2 expression and proliferation in NPC cell lines.
Conclusions.
Our study results revealed a novel role for the PPAR-γ–E2F2 pathway in controlling NPC cell proliferation and metastasis.
American Psychological Association (APA)
Yang, Ping-Li& Wang, Jia-Shun& Cheng, Xiao-Mei& Chen, Jing-Cai& Zhu, Hui& Li, Xiao-Lan…[et al.]. 2019. PPAR-γ Ligand Inhibits Nasopharyngeal Carcinoma Cell Proliferation and Metastasis by Regulating E2F2. PPAR Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1207155
Modern Language Association (MLA)
Yang, Ping-Li…[et al.]. PPAR-γ Ligand Inhibits Nasopharyngeal Carcinoma Cell Proliferation and Metastasis by Regulating E2F2. PPAR Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1207155
American Medical Association (AMA)
Yang, Ping-Li& Wang, Jia-Shun& Cheng, Xiao-Mei& Chen, Jing-Cai& Zhu, Hui& Li, Xiao-Lan…[et al.]. PPAR-γ Ligand Inhibits Nasopharyngeal Carcinoma Cell Proliferation and Metastasis by Regulating E2F2. PPAR Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1207155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207155