Retracted: Possible Role of Interaction between PPARα and Cyclophilin D in Cardioprotection of AMPK against In Vivo Ischemia-Reperfusion in Rats

Abstract EN

PPAR Research has retracted the article titled “ ” [1] due to errors found in the scientific content of the article.

We consulted our Editorial Board who believed that myocardial ischemia-reperfusion (IR) for only 24 hours should not induce an increase in the heart weight-to-body weight ratio because cardiac hypertrophy takes 1-2 weeks, though the authors argued that the increase was due to an inflammatory response, which disappears after 2-3 days.

The board queried what is meant when a 100% infarct area/total area ratio is reported for IR hearts, when the tetrazolium chloride (TTC) staining in Figure 1 shows a small area of infarct: the authors explained that the infarct size was normalized to the IR group as 100%.

The TTC images are of low technical quality: some hearts have 8 slices and others have 10, making the results difficult to analyze.

The infarcts in all groups are minor and TTC staining is minimal; many of the hearts have little ischemic injury and the board found the normalization misleading.

Although the authors provided the underlying data and images, the board recommended retraction.

The authors disagree with this decision.