Postoperative Analgesic Effects of Different Doses of Epidural Hydromorphone Coadministered with Ropivacaine after Cesarean Section: A Randomized Controlled Trial
Joint Authors
Yuwen, Tang
Yang, Meijuan
Wang, Luyang
Chen, Hong
Chen, Xinzhong
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
Single dose of epidural hydromorphone has been introduced to serve as an alternative method for postcesarean section analgesia.
However, optimal dose of epidural hydromorphone remains unknown.
Hence, we evaluated and compared the analgesic and adverse effects of postoperative different doses of epidural hydromorphone coadministered with ropivacaine after cesarean section.
Methods.
Eighty term parturients with elective cesarean section under epidural anesthesia were allocated into four groups.
Epidural analgesia was administered with an epidural bolus of either 0 mg (group H0), or 0.2 mg (group H1), or 0.4 mg (group H2), or 0.6 mg (group H3) hydromorphone coadministered with ropivacaine.
The primary outcome was the visual analogue pain scores (VAPSs) and rescue opioid consumption (PCIA with sulfentanil) in 24 hours.
Adverse effects such as respiratory depression, pruritus, nausea, and vomiting were recorded.
Results.
The VAPSs of group H1 at 2, 4, 6, 12 h and 24 h after surgery was similar to group H0.
The VAPSs of group H2 at 4 and 6 h postoperatively were significantly decreased when compared to group H0.
But, the VAPSs of group H2 at 2, 12, and 24 h postoperatively were similar to those of group H0.
The VAPSs of group H3 at 4, 6, 12 h, and 24 h after surgery were significantly decreased when compared to those of group H0.
The total sulfentanil consumption in 24 hours was 90 ± 26 μg in group H0, 75 ± 29 μg in group H1, 54 ± 32 μg in group H2, and 15 ± 16 μg in group H0.
Adverse effects were comparable in the four groups.
Conclusions.
Epidural administration of 0.6 mg hydromorphone coadministered with ropivacaine after cesarean section provided satisfactory pain relief with less sulfentanil consumption.
This trial is registered with ChiCTR-IPR-16010026.
American Psychological Association (APA)
Yang, Meijuan& Wang, Luyang& Chen, Hong& Yuwen, Tang& Chen, Xinzhong. 2019. Postoperative Analgesic Effects of Different Doses of Epidural Hydromorphone Coadministered with Ropivacaine after Cesarean Section: A Randomized Controlled Trial. Pain Research and Management،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1207403
Modern Language Association (MLA)
Yang, Meijuan…[et al.]. Postoperative Analgesic Effects of Different Doses of Epidural Hydromorphone Coadministered with Ropivacaine after Cesarean Section: A Randomized Controlled Trial. Pain Research and Management No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1207403
American Medical Association (AMA)
Yang, Meijuan& Wang, Luyang& Chen, Hong& Yuwen, Tang& Chen, Xinzhong. Postoperative Analgesic Effects of Different Doses of Epidural Hydromorphone Coadministered with Ropivacaine after Cesarean Section: A Randomized Controlled Trial. Pain Research and Management. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1207403
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207403