Modeling Parkinson’s Disease Using Induced Pluripotent Stem Cells
Joint Authors
Hu, Xinchao
Mao, Chengyuan
Fan, Liyuan
Luo, Haiyang
Hu, Zhengwei
Zhang, Shuo
Yang, Zhihua
Zheng, Huimin
Sun, Huifang
Fan, Yu
Yang, Jing
Shi, Changhe
Xu, Yuming
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-12
Country of Publication
Egypt
No. of Pages
15
Abstract EN
Parkinson’s disease (PD) is the second most common neurodegenerative disease.
The molecular mechanisms of PD at the cellular level involve oxidative stress, mitochondrial dysfunction, autophagy, axonal transport, and neuroinflammation.
Induced pluripotent stem cells (iPSCs) with patient-specific genetic background are capable of directed differentiation into dopaminergic neurons.
Cell models based on iPSCs are powerful tools for studying the molecular mechanisms of PD.
The iPSCs used for PD studies were mainly from patients carrying mutations in synuclein alpha (SNCA), leucine-rich repeat kinase 2 (LRRK2), PTEN-induced putative kinase 1 (PINK1), parkin RBR E3 ubiquitin protein ligase (PARK2), cytoplasmic protein sorting 35 (VPS35), and variants in glucosidase beta acid (GBA).
In this review, we summarized the advances in molecular mechanisms of Parkinson’s disease using iPSC models.
American Psychological Association (APA)
Hu, Xinchao& Mao, Chengyuan& Fan, Liyuan& Luo, Haiyang& Hu, Zhengwei& Zhang, Shuo…[et al.]. 2020. Modeling Parkinson’s Disease Using Induced Pluripotent Stem Cells. Stem Cells International،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1207589
Modern Language Association (MLA)
Hu, Xinchao…[et al.]. Modeling Parkinson’s Disease Using Induced Pluripotent Stem Cells. Stem Cells International No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1207589
American Medical Association (AMA)
Hu, Xinchao& Mao, Chengyuan& Fan, Liyuan& Luo, Haiyang& Hu, Zhengwei& Zhang, Shuo…[et al.]. Modeling Parkinson’s Disease Using Induced Pluripotent Stem Cells. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1207589
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207589