Small Molecule Epigenetic Modulators in Pure Chemical Cell Fate Conversion
Joint Authors
Yuan, Zhao-Di
Zhu, Wei-Ning
Liu, Ke-Zhi
Huang, Zhan-Peng
Han, Yan-Chuang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-21
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Although innovative technologies for somatic cell reprogramming and transdifferentiation provide new strategies for the research of translational medicine, including disease modeling, drug screening, artificial organ development, and cell therapy, recipient safety remains a concern due to the use of exogenous transcription factors during induction.
To resolve this problem, new induction approaches containing clinically applicable small molecules have been explored.
Small molecule epigenetic modulators such as DNA methylation writer inhibitors, histone methylation writer inhibitors, histone acylation reader inhibitors, and histone acetylation eraser inhibitors could overcome epigenetic barriers during cell fate conversion.
In the past few years, significant progress has been made in reprogramming and transdifferentiation of somatic cells with small molecule approaches.
In the present review, we systematically discuss recent achievements of pure chemical reprogramming and transdifferentiation.
American Psychological Association (APA)
Yuan, Zhao-Di& Zhu, Wei-Ning& Liu, Ke-Zhi& Huang, Zhan-Peng& Han, Yan-Chuang. 2020. Small Molecule Epigenetic Modulators in Pure Chemical Cell Fate Conversion. Stem Cells International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1208076
Modern Language Association (MLA)
Yuan, Zhao-Di…[et al.]. Small Molecule Epigenetic Modulators in Pure Chemical Cell Fate Conversion. Stem Cells International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1208076
American Medical Association (AMA)
Yuan, Zhao-Di& Zhu, Wei-Ning& Liu, Ke-Zhi& Huang, Zhan-Peng& Han, Yan-Chuang. Small Molecule Epigenetic Modulators in Pure Chemical Cell Fate Conversion. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1208076
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1208076