CTGF Attenuates Tendon-Derived StemProgenitor Cell Aging
Joint Authors
Li, Yingjuan
Rui, Yun-feng
Chen, Min-hao
Xiao, Long-fei
Geng, Peng
Wang, Pei
Xu, Zheng-yuan
Zhang, Xuan-pu
Dai, Guang-chun
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-11
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Aged tendon-derived stem/progenitor cells (TSPCs) lead to age-related tendon disorders and impair tendon healing.
However, the underlying molecular mechanisms of TSPC aging remain largely unknown.
Here, we investigated the role of connective tissue growth factor (CTGF) in TSPC aging.
CTGF protein and mRNA levels were markedly decreased in the aged TSPCs.
Moreover, recombinant CTGF attenuates TSPC aging and restores the age-associated reduction of self-renewal and differentiation of TSPCs.
In addition, cell cycle distribution of aged TSPCs was arrested in the G1/S phase while recombinant CTGF treatment promoted G1/S transition.
Recombinant CTGF also rescued decreased levels of cyclin D1 and CDK4 and reduced p27kip1 expression in aged TSPCs.
Our results demonstrated that CTGF plays a vital role in TSPC aging and might be a potential target for molecular therapy of age-related tendon disorders.
American Psychological Association (APA)
Rui, Yun-feng& Chen, Min-hao& Li, Yingjuan& Xiao, Long-fei& Geng, Peng& Wang, Pei…[et al.]. 2019. CTGF Attenuates Tendon-Derived StemProgenitor Cell Aging. Stem Cells International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1209259
Modern Language Association (MLA)
Rui, Yun-feng…[et al.]. CTGF Attenuates Tendon-Derived StemProgenitor Cell Aging. Stem Cells International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1209259
American Medical Association (AMA)
Rui, Yun-feng& Chen, Min-hao& Li, Yingjuan& Xiao, Long-fei& Geng, Peng& Wang, Pei…[et al.]. CTGF Attenuates Tendon-Derived StemProgenitor Cell Aging. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1209259
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209259