![](/images/graphics-bg.png)
Interleukin-1β Enhances Umbilical Cord Mesenchymal Stem Cell Adhesion Ability on Human Umbilical Vein Endothelial Cells via LFA-1ICAM-1 Interaction
Joint Authors
Wang, Hwai-Shi
Wu, Tsai-Yi
Liang, Ya-Han
Wu, Jiahn-Chun
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-27
Country of Publication
Egypt
No. of Pages
13
Abstract EN
The migration of administered mesenchymal stem cells (MSCs) to sites of injury via the bloodstream has been demonstrated.
However, the underlying mechanisms of umbilical cord MSC adhesion to endothelial cells during transendothelial migration are still unclear.
In this study, our data showed that IL-1β induced LFA-1 expression on MSCs and ICAM-1 expression on HUVECs.
We then pretreated MSCs with protein synthesis inhibitor cycloheximide.
The results showed that IL-1β induced LFA-1 expression on the surface of MSCs via the protein synthesis pathway.
Through the p38 MAPK signaling pathway inhibitor SB 203580, we found that IL-1β induces the expression of LFA-1 through p38 MAPK signaling and enhances ICAM-1 expression in HUVECs.
In addition, IL-1β-induced MSC adhesion to HUVECs was found to be inhibited by IL-1RA and the LFA-1 inhibitor lovastatin.
These results indicate that IL-1β promotes the cell adhesion of MSCs to HUVECs through LFA-1/ICAM-1 interaction.
We address the evidence that the cell adhesion mechanism of IL-1β promotes MSC adhesion to HUVECs.
The implications of these findings could enhance the therapeutic potential of MSCs.
American Psychological Association (APA)
Wu, Tsai-Yi& Liang, Ya-Han& Wu, Jiahn-Chun& Wang, Hwai-Shi. 2019. Interleukin-1β Enhances Umbilical Cord Mesenchymal Stem Cell Adhesion Ability on Human Umbilical Vein Endothelial Cells via LFA-1ICAM-1 Interaction. Stem Cells International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1209516
Modern Language Association (MLA)
Wu, Tsai-Yi…[et al.]. Interleukin-1β Enhances Umbilical Cord Mesenchymal Stem Cell Adhesion Ability on Human Umbilical Vein Endothelial Cells via LFA-1ICAM-1 Interaction. Stem Cells International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1209516
American Medical Association (AMA)
Wu, Tsai-Yi& Liang, Ya-Han& Wu, Jiahn-Chun& Wang, Hwai-Shi. Interleukin-1β Enhances Umbilical Cord Mesenchymal Stem Cell Adhesion Ability on Human Umbilical Vein Endothelial Cells via LFA-1ICAM-1 Interaction. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1209516
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209516