Motor Improvement of Skilled Forelimb Use Induced by Treatment with Growth Hormone and Rehabilitation Is Dependent on the Onset of the Treatment after Cortical Ablation
Joint Authors
Heredia, Margarita
Palomero, Jesús
de la Fuente, Antonio
Criado, José María
Yajeya, Javier
Devesa, Jesús
Devesa, Pablo
Vicente-Villardón, José Luis
Riolobos, Adelaida S.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-20
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
We previously demonstrated that the administration of GH immediately after severe motor cortex injury, in rats, followed by rehabilitation, improved the functionality of the affected limb and reexpressed nestin in the contralateral motor cortex.
Here, we analyze whether these GH effects depend on a time window after the injury and on the reexpression of nestin and actin.
Injured animals were treated with GH (0.15 mg/kg/day) or vehicle, at days 7, 14, and 35 after cortical ablation.
Rehabilitation was applied at short and long term (LTR) after the lesion and then sacrificed.
Nestin and actin were analyzed by immunoblotting in the contralateral motor cortex.
Giving GH at days 7 or 35 after the lesion, but not 14 days after it, led to a remarkable improvement in the functionality of the affected paw.
Contralateral nestin and actin reexpression was clearly higher in GH-treated animals, probably because compensatory brain plasticity was established.
GH and immediate rehabilitation are key for repairing brain injuries, with the exception of a critical time period: GH treatment starting 14 days after the lesion.
Our data also indicate that there is not a clear plateau in the recovery from a brain injury in agreement with our data in human patients.
American Psychological Association (APA)
Heredia, Margarita& Palomero, Jesús& de la Fuente, Antonio& Criado, José María& Yajeya, Javier& Devesa, Jesús…[et al.]. 2018. Motor Improvement of Skilled Forelimb Use Induced by Treatment with Growth Hormone and Rehabilitation Is Dependent on the Onset of the Treatment after Cortical Ablation. Neural Plasticity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1210247
Modern Language Association (MLA)
Heredia, Margarita…[et al.]. Motor Improvement of Skilled Forelimb Use Induced by Treatment with Growth Hormone and Rehabilitation Is Dependent on the Onset of the Treatment after Cortical Ablation. Neural Plasticity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1210247
American Medical Association (AMA)
Heredia, Margarita& Palomero, Jesús& de la Fuente, Antonio& Criado, José María& Yajeya, Javier& Devesa, Jesús…[et al.]. Motor Improvement of Skilled Forelimb Use Induced by Treatment with Growth Hormone and Rehabilitation Is Dependent on the Onset of the Treatment after Cortical Ablation. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1210247
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210247