Effect of Maternal Administration of Edible Bird’s Nest on the Learning and Memory Abilities of Suckling Offspring in Mice
Joint Authors
Xie, Yong
Zhang, Yi
Zeng, Hongliang
Zheng, Baodong
Huang, Zhiji
Xu, Hui
Fan, Qunyan
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Although human brains continue developing throughout the underage developmental stages, the infancy period is considered the most important one for the whole life.
It has been reported that sialic acid from edible bird’s nest (EBN) can facilitate the development of brain and intelligence.
In this study, by oral administration of EBN to female mice during the pregnancy or lactation period, the effects of EBN on the levels of sialic acid in mouse milk were determined using high-performance liquid chromatography (HPLC).
Furthermore, the spatial learning performances of their offspring were assessed using the Morris water maze test.
Additionally, cerebral malondialdehyde (MDA), superoxide dismutase (SOD), choline acetyltransferase (ChAT), and acetylcholinesterase (AChE) in cubs nursed by the female mice given the EBN homogenate were examined, while BDNF immunohistochemical staining and neuron count in hippocampi were investigated as well.
These results showed that administration with EBN in maternal mice during pregnancy or lactation period can improve the learning and memory functions in their offspring, possibly by increasing the activities of SOD and ChAT and, at the meantime, decreasing the levels of MDA and activities of AChE.
Moreover, BDNF levels for CA1, CA2, and CA3 regions in hippocampi and the numbers of dyed neurons in CA1, CA2, CA3, and DG regions among the offspring were significantly enhanced due to the intake of EBN by the maternal mice.
We concluded that maternal administration of EBN during the pregnancy and lactation periods can improve the spatial learning performances in the offspring.
American Psychological Association (APA)
Xie, Yong& Zeng, Hongliang& Huang, Zhiji& Xu, Hui& Fan, Qunyan& Zhang, Yi…[et al.]. 2018. Effect of Maternal Administration of Edible Bird’s Nest on the Learning and Memory Abilities of Suckling Offspring in Mice. Neural Plasticity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1210378
Modern Language Association (MLA)
Xie, Yong…[et al.]. Effect of Maternal Administration of Edible Bird’s Nest on the Learning and Memory Abilities of Suckling Offspring in Mice. Neural Plasticity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1210378
American Medical Association (AMA)
Xie, Yong& Zeng, Hongliang& Huang, Zhiji& Xu, Hui& Fan, Qunyan& Zhang, Yi…[et al.]. Effect of Maternal Administration of Edible Bird’s Nest on the Learning and Memory Abilities of Suckling Offspring in Mice. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1210378
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210378