Tumor Necrosis Factor and Interleukin-1β Modulate Synaptic Plasticity during Neuroinflammation
Joint Authors
Rizzo, Francesca Romana
Musella, Alessandra
De Vito, Francesca
Fresegna, Diego
Bullitta, Silvia
Vanni, Valentina
Guadalupi, Livia
Stampanoni Bassi, Mario
Buttari, Fabio
Mandolesi, Georgia
Centonze, Diego
Gentile, Antonietta
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Cytokines are constitutively released in the healthy brain by resident myeloid cells to keep proper synaptic plasticity, either in the form of Hebbian synaptic plasticity or of homeostatic plasticity.
However, when cytokines dramatically increase, establishing a status of neuroinflammation, the synaptic action of such molecules remarkably interferes with brain circuits of learning and cognition and contributes to excitotoxicity and neurodegeneration.
Among others, interleukin-1β (IL-1β) and tumor necrosis factor (TNF) are the best studied proinflammatory cytokines in both physiological and pathological conditions and have been invariably associated with long-term potentiation (LTP) (Hebbian synaptic plasticity) and synaptic scaling (homeostatic plasticity), respectively.
Multiple sclerosis (MS) is the prototypical neuroinflammatory disease, in which inflammation triggers excitotoxic mechanisms contributing to neurodegeneration.
IL-β and TNF are increased in the brain of MS patients and contribute to induce the changes in synaptic plasticity occurring in MS patients and its animal model, the experimental autoimmune encephalomyelitis (EAE).
This review will introduce and discuss current evidence of the role of IL-1β and TNF in the regulation of synaptic strength at both physiological and pathological levels, in particular speculating on their involvement in the synaptic plasticity changes observed in the EAE brain.
American Psychological Association (APA)
Rizzo, Francesca Romana& Musella, Alessandra& De Vito, Francesca& Fresegna, Diego& Bullitta, Silvia& Vanni, Valentina…[et al.]. 2018. Tumor Necrosis Factor and Interleukin-1β Modulate Synaptic Plasticity during Neuroinflammation. Neural Plasticity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210466
Modern Language Association (MLA)
Rizzo, Francesca Romana…[et al.]. Tumor Necrosis Factor and Interleukin-1β Modulate Synaptic Plasticity during Neuroinflammation. Neural Plasticity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1210466
American Medical Association (AMA)
Rizzo, Francesca Romana& Musella, Alessandra& De Vito, Francesca& Fresegna, Diego& Bullitta, Silvia& Vanni, Valentina…[et al.]. Tumor Necrosis Factor and Interleukin-1β Modulate Synaptic Plasticity during Neuroinflammation. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210466