Beneficial Effects Exerted by Paeonol in the Management of Atherosclerosis
Joint Authors
Lu, Li
Qin, Yating
Guo, Xiaomei
Chen, Chen
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Atherosclerosis, a chronic luminal stenosis disorder occurred in large and medium arteries, is the principle pathological basis of cardiovascular diseases with the highest morbidity and mortality worldwide.
In oriental countries, traditional Chinese medicine Cortex Moutan has been widely used for the treatment of atherosclerosis-related illnesses for thousands of years.
Paeonol, a bioactive monomer extracted from Cortex Moutan, is an important pharmacological component responsible for the antiatherosclerotic effects.
Numerous lines of findings have established that paeonol offers beneficial roles against the initiation and progression of atherosclerotic lesions through inhibiting proatherogenic processes, such as endothelium damage, chronic inflammation, disturbance of lipid metabolism, uncontrolled oxidative stress, excessive growth, and mobilization of vascular smooth muscle cells as well as abnormality of platelet activation.
Investigations identifying the atheroprotective effects of paeonol present substantial evidence for potential clinical application of paeonol as a therapeutic agent in atherosclerosis management.
In this review, we summarize the antiatherosclerotic actions by which paeonol suppresses atherogenesis and provide newly insights into its atheroprotective mechanisms and the future clinical practice.
American Psychological Association (APA)
Lu, Li& Qin, Yating& Chen, Chen& Guo, Xiaomei. 2018. Beneficial Effects Exerted by Paeonol in the Management of Atherosclerosis. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1210827
Modern Language Association (MLA)
Lu, Li…[et al.]. Beneficial Effects Exerted by Paeonol in the Management of Atherosclerosis. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1210827
American Medical Association (AMA)
Lu, Li& Qin, Yating& Chen, Chen& Guo, Xiaomei. Beneficial Effects Exerted by Paeonol in the Management of Atherosclerosis. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1210827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210827