Honokiol Protects against Anti-β1-Adrenergic Receptor Autoantibody-Induced Myocardial Dysfunction via Activation of Autophagy
Joint Authors
Wei, Xi-qing
Zhang, Hong-sheng
Wei, Guang-he
Zhang, Jin-guo
Du, Yan-yan
Tan, Hong-yong
Yang, Jun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Myocardial diseases are prevalent syndromes with high mortality rate.
The exploration of effective interference is important.
Anti-β1-adrenergic receptor autoantibody (β1-AAB) is highly correlated with myocardial dysfunction.
The actions and underlying mechanisms of honokiol (HNK) in β1-AAB-positive patients await to be unraveled.
In this study, we established a rat model of β1-AAB positive with myocardial dysfunction.
Cardiac function following β1-AR-ECII administration was analyzed using the VisualSonics Vevo 770 High-Resolution In Vivo Imaging System.
The levels of autophagy-related proteins were detected by Western blotting.
Our data revealed that HNK reversed β1-AAB-induced effects and protected myocardial tissues from dysfunction.
After HNK treatment, the cardiac contractile ability increased and the LDH activity decreased.
HNK attenuated myocardial degeneration.
In addition, HNK promoted the activation of the AMP-dependent protein kinase/Unc-51-like autophagy activating kinase (AMPK/ULK) pathway and activated autophagy.
These results suggest that HNK protects against β1-AAB-induced myocardial dysfunction via activation of autophagy and it may be a potentially therapeutic compound for β1-AAB-positive myocardial diseases.
American Psychological Association (APA)
Wei, Xi-qing& Zhang, Hong-sheng& Wei, Guang-he& Zhang, Jin-guo& Du, Yan-yan& Tan, Hong-yong…[et al.]. 2018. Honokiol Protects against Anti-β1-Adrenergic Receptor Autoantibody-Induced Myocardial Dysfunction via Activation of Autophagy. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210894
Modern Language Association (MLA)
Wei, Xi-qing…[et al.]. Honokiol Protects against Anti-β1-Adrenergic Receptor Autoantibody-Induced Myocardial Dysfunction via Activation of Autophagy. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1210894
American Medical Association (AMA)
Wei, Xi-qing& Zhang, Hong-sheng& Wei, Guang-he& Zhang, Jin-guo& Du, Yan-yan& Tan, Hong-yong…[et al.]. Honokiol Protects against Anti-β1-Adrenergic Receptor Autoantibody-Induced Myocardial Dysfunction via Activation of Autophagy. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210894
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210894