Sodium Ferulate Attenuates Lidocaine-Induced Corneal Endothelial Impairment
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The introduction of intracameral anaesthesia by injection of lidocaine has become popular in cataract surgery for its inherent potency, rapid onset, tissue penetration, and efficiency.
However, intracameral lidocaine causes corneal thickening, opacification, and corneal endothelial cell loss.
Herein, we investigated the effects of lidocaine combined with sodium ferulate, an antioxidant with antiapoptotic and anti-inflammatory properties, on lidocaine-induced damage of corneal endothelia with in vitro experiment of morphological changes and cell viability of cultured human corneal endothelial cells and in vivo investigation of corneal endothelial cell density and central corneal thickness of cat eyes.
Our finding indicates that sodium ferulate from 25 to 200 mg/L significantly reduced 2 g/L lidocaine-induced toxicity to human corneal endothelial cells, and 50 mg/L sodium ferulate recovered the damaged human corneal endothelial cells to normal growth status.
Furthermore, 100 mg/L sodium ferulate significantly inhibited lidocaine-induced corneal endothelial cell loss and corneal thickening in cat eyes.
In conclusion, sodium ferulate protects human corneal endothelial cells from lidocaine-induced cytotoxicity and attenuates corneal endothelial cell loss and central corneal thickening of cat eyes after intracameral injection with lidocaine.
It is likely that the antioxidant effect of sodium ferulate reduces the cytotoxic and inflammatory corneal reaction during intracameral anaesthesia.
American Psychological Association (APA)
Jiang, Guojian& Fan, Tingjun. 2018. Sodium Ferulate Attenuates Lidocaine-Induced Corneal Endothelial Impairment. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211536
Modern Language Association (MLA)
Jiang, Guojian& Fan, Tingjun. Sodium Ferulate Attenuates Lidocaine-Induced Corneal Endothelial Impairment. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1211536
American Medical Association (AMA)
Jiang, Guojian& Fan, Tingjun. Sodium Ferulate Attenuates Lidocaine-Induced Corneal Endothelial Impairment. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211536