Benefit of Oleuropein Aglycone for Alzheimer’s Disease by Promoting Autophagy
Joint Authors
Gargini, Ricardo
Avila, Jesús
García-Escudero, Vega
Cordero, Joaquín G.
García-Escudero, Ramón
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Alzheimer’s disease is a proteinopathy characterized by accumulation of hyperphosphorylated Tau and β-amyloid.
Autophagy is a physiological process by which aggregated proteins and damaged organelles are eliminated through lysosomal digestion.
Autophagy deficiency has been demonstrated in Alzheimer’s patients impairing effective elimination of aggregates and damaged mitochondria, leading to their accumulation, increasing their toxicity and oxidative stress.
In the present study, we demonstrated by microarray analysis the downregulation of fundamental autophagy and mitophagy pathways in Alzheimer’s patients.
The benefits of the Mediterranean diet on Alzheimer’s disease and cognitive impairment are well known, attributing this effect to several polyphenols, such as oleuropein aglycone (OLE), present in extra virgin olive oil.
OLE is able to induce autophagy, achieving a decrease of aggregated proteins and a reduction of cognitive impairment in vivo.
This effect is caused by the modulation of several pathways including the AMPK/mTOR axis and the activation of autophagy gene expression mediated by sirtuins and histone acetylation or EB transcription factor.
We propose that supplementation of diet with extra virgin olive oil might have potential benefits for Alzheimer’s patients by the induction of autophagy by OLE.
American Psychological Association (APA)
Cordero, Joaquín G.& García-Escudero, Ramón& Avila, Jesús& Gargini, Ricardo& García-Escudero, Vega. 2018. Benefit of Oleuropein Aglycone for Alzheimer’s Disease by Promoting Autophagy. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211555
Modern Language Association (MLA)
Cordero, Joaquín G.…[et al.]. Benefit of Oleuropein Aglycone for Alzheimer’s Disease by Promoting Autophagy. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211555
American Medical Association (AMA)
Cordero, Joaquín G.& García-Escudero, Ramón& Avila, Jesús& Gargini, Ricardo& García-Escudero, Vega. Benefit of Oleuropein Aglycone for Alzheimer’s Disease by Promoting Autophagy. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211555
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211555