Regulated Cell Death as a Therapeutic Target for Novel Antifungal Peptides and Biologics
Joint Authors
Büttner, Sabrina
Yeaman, Michael R.
Thevissen, Karin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-26
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
The rise of microbial pathogens refractory to conventional antibiotics represents one of the most urgent and global public health concerns for the 21st century.
Emergence of Candida auris isolates and the persistence of invasive mold infections that resist existing treatment and cause severe illness has underscored the threat of drug-resistant fungal infections.
To meet these growing challenges, mechanistically novel agents and strategies are needed that surpass the conventional fungistatic or fungicidal drug actions.
Host defense peptides have long been misunderstood as indiscriminant membrane detergents.
However, evidence gathered over the past decade clearly points to their sophisticated and selective mechanisms of action, including exploiting regulated cell death pathways of their target pathogens.
Such peptides perturb transmembrane potential and mitochondrial energetics, inducing phosphatidylserine accessibility and metacaspase activation in fungi.
These mechanisms are often multimodal, affording target pathogens fewer resistance options as compared to traditional small molecule drugs.
Here, recent advances in the field are examined regarding regulated cell death subroutines as potential therapeutic targets for innovative anti-infective peptides against pathogenic fungi.
Furthering knowledge of protective host defense peptide interactions with target pathogens is key to advancing and applying novel prophylactic and therapeutic countermeasures to fungal resistance and pathogenesis.
American Psychological Association (APA)
Yeaman, Michael R.& Büttner, Sabrina& Thevissen, Karin. 2018. Regulated Cell Death as a Therapeutic Target for Novel Antifungal Peptides and Biologics. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1211637
Modern Language Association (MLA)
Yeaman, Michael R.…[et al.]. Regulated Cell Death as a Therapeutic Target for Novel Antifungal Peptides and Biologics. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-20.
https://search.emarefa.net/detail/BIM-1211637
American Medical Association (AMA)
Yeaman, Michael R.& Büttner, Sabrina& Thevissen, Karin. Regulated Cell Death as a Therapeutic Target for Novel Antifungal Peptides and Biologics. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1211637
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211637