The Effect of MitoQ on Aging-Related Biomarkers: A Systematic Review and Meta-Analysis
Joint Authors
Braakhuis, Andrea J.
Nagulan, Rohith
Somerville, Vaughan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Mitochondria are metabolically active organelles that produce significant reactive oxygen species, linked with aging and degenerative diseases.
In recent years, particular focus has been put on mitochondria-targeted antioxidants, to decrease the concentration of reactive oxygen species and help alleviate the accumulation of oxidative damage and associated aging.
MitoQ is a mitochondria-targeted antioxidant of which is reported to support healthy aging.
The aim of this systematic review is to investigate the effects of MitoQ on oxidative outcomes related to the aging process.
A predeveloped search strategy was run against MEDLINE (Ovid), EMBASE (Ovid), and CINAHL databases, which identified 10,255 articles of interest, with 27 of these finalised for use after screening.
Three outcomes had sufficient data to meta-analyse nitrotyrosine concentration (190 animals, SMD −0.67, 95% CI (−1.30, −0.05), p=0.04), membrane potential (63 animals, MD 11.44, 95% CI (1.28–21.60), p=0.03), and protein carbonyl concentration (182 animals, SMD −0.13, 95% CI (−0.44, 0.18), p=0.41).
MitoQ intervention produced a statistically significant reduction in nitrotyrosine concentration and increased membrane potential.
MitoQ may be of some benefit in alleviating oxidative stress related to aging.
American Psychological Association (APA)
Braakhuis, Andrea J.& Nagulan, Rohith& Somerville, Vaughan. 2018. The Effect of MitoQ on Aging-Related Biomarkers: A Systematic Review and Meta-Analysis. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1212271
Modern Language Association (MLA)
Braakhuis, Andrea J.…[et al.]. The Effect of MitoQ on Aging-Related Biomarkers: A Systematic Review and Meta-Analysis. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1212271
American Medical Association (AMA)
Braakhuis, Andrea J.& Nagulan, Rohith& Somerville, Vaughan. The Effect of MitoQ on Aging-Related Biomarkers: A Systematic Review and Meta-Analysis. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1212271
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212271