Osteogenic Induction of Wharton’s Jelly-Derived Mesenchymal Stem Cell for Bone Regeneration: A Systematic Review

Joint Authors

Idrus, Ruszymah Bt Hj
Yazid, Muhammad Dain
Ansari, Ayu Suraya
Sainik, Nur Qisya Afifah Veronica
Razali, Rabiatul Adawiyah
Bin Saim, Aminuddin

Source

Stem Cells International

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-17, 17 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-11-11

Country of Publication

Egypt

No. of Pages

17

Abstract EN

Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) are emerging as a promising source for bone regeneration in the treatment of bone defects.

Previous studies have reported the ability of WJ-MSCs to be induced into the osteogenic lineage.

The purpose of this review was to systematically assess the potential of WJ-MSC differentiation into the osteogenic lineage.

A comprehensive search was conducted in Medline via Ebscohost and Scopus, where relevant studies published between 1961 and 2018 were selected.

The main inclusion criteria were that articles must be primary studies published in English evaluating osteogenic induction of WJ-MSCs.

The literature search identified 92 related articles, but only 18 articles met the inclusion criteria.

These include two animal studies, three articles containing both in vitro and in vivo assessments, and 13 articles on in vitro studies, all of which are discussed in this review.

There were two types of osteogenic induction used in these studies, either chemical or physical.

The studies demonstrate that WJ-MSCs are able to differentiate into osteogenic lineage and promote osteogenesis.

In light of these observations, it is suggested that WJ-MSCs can be a potential source of stem cells for osteogenic induction, as an alternative to bone marrow-derived mesenchymal stem cells.

American Psychological Association (APA)

Ansari, Ayu Suraya& Yazid, Muhammad Dain& Sainik, Nur Qisya Afifah Veronica& Razali, Rabiatul Adawiyah& Bin Saim, Aminuddin& Idrus, Ruszymah Bt Hj. 2018. Osteogenic Induction of Wharton’s Jelly-Derived Mesenchymal Stem Cell for Bone Regeneration: A Systematic Review. Stem Cells International،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1213292

Modern Language Association (MLA)

Ansari, Ayu Suraya…[et al.]. Osteogenic Induction of Wharton’s Jelly-Derived Mesenchymal Stem Cell for Bone Regeneration: A Systematic Review. Stem Cells International No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1213292

American Medical Association (AMA)

Ansari, Ayu Suraya& Yazid, Muhammad Dain& Sainik, Nur Qisya Afifah Veronica& Razali, Rabiatul Adawiyah& Bin Saim, Aminuddin& Idrus, Ruszymah Bt Hj. Osteogenic Induction of Wharton’s Jelly-Derived Mesenchymal Stem Cell for Bone Regeneration: A Systematic Review. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1213292

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1213292