Tissue Engineering of Large Full-Size Meniscus Defects by a Polyurethane Scaffold: Accelerated Regeneration by Mesenchymal Stromal Cells
Joint Authors
Zellner, Johannes
Kujat, Richard
Lang, Siegmund
Pfeifer, Christian G.
Koch, Matthias
Angele, Peter
Pattappa, Girish
Achatz, Felix P.
Nerlich, Michael
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-07
Country of Publication
Egypt
No. of Pages
11
Abstract EN
The endogenous healing potential of avascular meniscal lesions is poor.
Up to now, partial meniscectomy is still the treatment of choice for meniscal lesions within the avascular area.
However, the large loss of meniscus substance predisposes the knee for osteoarthritic changes.
Tissue engineering techniques for the replacement of such lesions could be a promising alternative treatment option.
Thus, a polyurethane scaffold, which is already in clinical use, loaded with mesenchymal stromal cells, was analyzed for the repair of critical meniscus defects in the avascular zone.
Large, approximately 7 mm broad meniscus lesions affecting both the avascular and vascular area of the lateral rabbit meniscus were treated with polyurethane scaffolds either loaded or unloaded with mesenchymal stromal cells.
Menisci were harvested at 6 and 12 weeks after initial surgery.
Both cell-free and cell-loaded approaches led to well-integrated and stable meniscus-like repair tissue.
However, an accelerated healing was achieved by the application of mesenchymal stromal cells.
Dense vascularization was detected throughout the repair tissue of both treatment groups.
Overall, the polyurethane scaffold seems to promote the vessel ingrowth.
The application of mesenchymal stromal cells has the potential to speed up the healing process.
American Psychological Association (APA)
Koch, Matthias& Achatz, Felix P.& Lang, Siegmund& Pfeifer, Christian G.& Pattappa, Girish& Kujat, Richard…[et al.]. 2018. Tissue Engineering of Large Full-Size Meniscus Defects by a Polyurethane Scaffold: Accelerated Regeneration by Mesenchymal Stromal Cells. Stem Cells International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1213596
Modern Language Association (MLA)
Koch, Matthias…[et al.]. Tissue Engineering of Large Full-Size Meniscus Defects by a Polyurethane Scaffold: Accelerated Regeneration by Mesenchymal Stromal Cells. Stem Cells International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1213596
American Medical Association (AMA)
Koch, Matthias& Achatz, Felix P.& Lang, Siegmund& Pfeifer, Christian G.& Pattappa, Girish& Kujat, Richard…[et al.]. Tissue Engineering of Large Full-Size Meniscus Defects by a Polyurethane Scaffold: Accelerated Regeneration by Mesenchymal Stromal Cells. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1213596
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213596