Ion Transport Modulators as Antimycobacterial Agents
Joint Authors
Handunnetti, Shiroma M.
Mitini-Nkhoma, Steven C.
Fernando, Narmada
Ishaka, G. K. D.
Pathirana, Sisira L.
Source
Tuberculosis Research and Treatment
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
There is an urgent need for better and safer therapeutic interventions for tuberculosis (TB).
We assessed the effects of FDA-approved ion transport modulators, namely, ambroxol HCl, amiloride HCl, diazoxide, digoxin, furosemide, hydrochlorothiazide (HCTZ), metformin, omeprazole, pantoprazole, phenytoin, verapamil, and drug X and Y on the growth of free and intracellular Mycobacterium bovis BCG.
Free and intracellular M.
bovis BCG were cultured in the presence or absence of the test drugs for 3 to 9 days and then quantified.
For both free and intracellular bacteria, cultures that were exposed to furosemide, phenytoin, or drug Y yielded lower bacteria counts compared to drug-free controls (p<0.05).
The same was observed with diazoxide, HCTZ, verapamil, and drug X, but only for intracellular M.
bovis BCG (p<0.05).
To assess the effects of the drugs on bactericidal activity of rifampicin, free and intracellular M.
bovis BCG were treated with rifampicin alone or in combination with each of the thirteen test drugs for 3 to 9 days.
For extracellular bacteria, higher bacteria clearance rates were observed in cultures exposed to rifampicin in combination with amiloride HCl, diazoxide, digoxin, furosemide, HCTZ, metformin, pantoprazole, phenytoin, drug X, or drug Y than those exposed to rifampicin alone, indicating that rifampicin had a synergistic effect with these test drugs.
Rifampicin was also synergistic with ambroxol HCl, diazoxide, digoxin, furosemide, HCTZ, omeprazole, pantoprazole, phenytoin, verapamil, and drug X against intracellular M.
bovis BCG.
The antimycobacterial properties exhibited by the ion transport modulators in this study make them viable candidates as adjuncts to the current anti-TB regimens.
American Psychological Association (APA)
Mitini-Nkhoma, Steven C.& Fernando, Narmada& Ishaka, G. K. D.& Handunnetti, Shiroma M.& Pathirana, Sisira L.. 2020. Ion Transport Modulators as Antimycobacterial Agents. Tuberculosis Research and Treatment،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1213733
Modern Language Association (MLA)
Mitini-Nkhoma, Steven C.…[et al.]. Ion Transport Modulators as Antimycobacterial Agents. Tuberculosis Research and Treatment No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1213733
American Medical Association (AMA)
Mitini-Nkhoma, Steven C.& Fernando, Narmada& Ishaka, G. K. D.& Handunnetti, Shiroma M.& Pathirana, Sisira L.. Ion Transport Modulators as Antimycobacterial Agents. Tuberculosis Research and Treatment. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1213733
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213733