Development of date fruit nanoparticles and investigating its effect on Pseudomonas aeruginosa biofilm

Other Title(s)

تطوير الجزيئات النانوية لثمار التمر و معرفة تأثيرها على الأغشية الحيوية للبكتيريا الزائفة الزنجارية

Dissertant

Abu Ras, Hadil Jamal

Thesis advisor

al-Zumayli, Iman

University

Isra University

Faculty

Faculty of Pharmacy

University Country

Jordan

Degree

Master

Degree Date

2021

English Abstract

Cystic fibrosis (CF) patients suffer from recurrent lung infections mainly bacterial infection such as staphylococcus aureus (S.

aureus) and Pseudomonas aeruginosa (P.

aeruginosa).

Although prophylactic antibiotics are usually prescribed, bacterial resistance is a key challenge.

Therefore, there are attempts to identify new antibiotics, particularly those from natural sources, that may enhance the prognosis of the disease.

Therefore, the aim of this project was to investigate the use of date fruit extracts as a potential candidate for the development of dry powder inhaler (DPI) with potential biological activity against P.

aeruginosa.

Date fruit (Phoenix dactylifera L.) consists of flavonoids, polyphenols, minerals and vitamins, and in many studies, it was reported that it had an effect on gram-positive and gram-negative bacteria.

When talking about lung diseases, the pulmonary route for drug delivery provides special advantages when compared with other routes.

The drugs can reach the site of action more efficiently.

Dry powder inhaler (DPI) was employed to deliver the powder formulations.

Aqueous date fruit extract: chitosan-based nanoparticles with increasing concentration of chitosan were prepared.

Chitosan 0.05% w/v nanoparticles demonstrated the highest encapsulation efficiency (55.91%) and delivered the highest emitted dose (98.92%) and Fine particle fraction of nominated dose (42.62%).

Chitosan date nanoparticles (CDN) showed MIC of 4.5 mg/ml and demonstrated a significant inhibition of biofilm formation.

CDN is suggested as a potential candidate for the management of cystic fibrosis as an DPI.

Main Topic

Pharmacology

No. of Pages

66

Table of Contents

Table of contents.

Abstract.

Abstract in Arabic.

Chapter One : Introduction.

Chapter Two : Literature review.

Chapter Three : Materials and method.

Chapter Four : Results and discussion.

Conclusions.

References.

American Psychological Association (APA)

Abu Ras, Hadil Jamal. (2021). Development of date fruit nanoparticles and investigating its effect on Pseudomonas aeruginosa biofilm. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-1269026

Modern Language Association (MLA)

Abu Ras, Hadil Jamal. Development of date fruit nanoparticles and investigating its effect on Pseudomonas aeruginosa biofilm. (Master's theses Theses and Dissertations Master). Isra University. (2021).
https://search.emarefa.net/detail/BIM-1269026

American Medical Association (AMA)

Abu Ras, Hadil Jamal. (2021). Development of date fruit nanoparticles and investigating its effect on Pseudomonas aeruginosa biofilm. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-1269026

Language

English

Data Type

Arab Theses

Record ID

BIM-1269026