نسب الخلايا التائية المساعدة (Th2 و Th1 وTh17) في الدوران لدى مريضات سرطان الثدي و مريضات الأورام الحميدة في الثدي
Other Title(s)
Circulating frequencies of T helper (Th1, Th2, and Th17) cells in breast cancer patients and women with benign breast tumors
Joint Authors
الصالح، جمانة
أبو فخر، فيحاء
مرام بلال
Source
مجلة المجلس العربي للاختصاصات الصحية
Issue
Vol. 21, Issue 1 (31 Mar. 2020), pp.28-37, 10 p.
Publisher
The Arab Board of Health Specializations
Publication Date
2020-03-31
Country of Publication
Syria
No. of Pages
10
Main Subjects
Abstract EN
Objective: Dysfunction of systemic immunity may be involved in the establishment of advanced breast cancer.
Therefore, it is important to understand immune-regulation via estimation of T helper (Th1, Th2 and Th17) cell frequencies in peripheral blood of breast cancer patients.
Methods: Sixty nine patients with breast tumors were enrolled in this study.
Based on pathologic diagnostic assessment, patients were divided into two categories: patients affected with benign breast tumors (n=28) with age range (26-79) years, and breast cancer patients (n=41) with age range (22-74) years.
This study investigated the distribution of Th1 (CD4+IFNy+), Th2 (CD4+IL-4+) and Th17 (CD4+IL-17+) in peripheral blood mononuclear cells (PBMCs) from two studied groups.
Cells were evaluated by flow cytometry and reported as a percentage of total CD4+ cells.
The present study also assessed the association of cell percentages with clinicopathological parameters.
Results: Compared with patients of benign breast tumors, an increase in the peripheral percentages of Th1 and Th2 was observed in breast cancer patients, while the percentage of Th17 cells increased.
However; no significant difference of cell percentages was found between the two studied groups.
Elevation of Th2 frequency in breast cancer patients correlated with lymph node metastasis.
However; no significant association was recognized between the frequencies of other cell subtypes and clinicopathological factors.
Conclusions: We observed significantly increased percentage of circulating Th2 cells in breast cancer patients with metastasis.
These results indicate that Th2 may play an important role in metastasis of breast malignancy.
American Psychological Association (APA)
مرام بلال والصالح، جمانة وأبو فخر، فيحاء. 2020. نسب الخلايا التائية المساعدة (Th2 و Th1 وTh17) في الدوران لدى مريضات سرطان الثدي و مريضات الأورام الحميدة في الثدي. مجلة المجلس العربي للاختصاصات الصحية،مج. 21، ع. 1، ص ص. 28-37.
https://search.emarefa.net/detail/BIM-1272019
Modern Language Association (MLA)
مرام بلال....[و آخرون]. نسب الخلايا التائية المساعدة (Th2 و Th1 وTh17) في الدوران لدى مريضات سرطان الثدي و مريضات الأورام الحميدة في الثدي. مجلة المجلس العربي للاختصاصات الصحية مج. 21، ع. 1 (2020)، ص ص. 28-37.
https://search.emarefa.net/detail/BIM-1272019
American Medical Association (AMA)
مرام بلال والصالح، جمانة وأبو فخر، فيحاء. نسب الخلايا التائية المساعدة (Th2 و Th1 وTh17) في الدوران لدى مريضات سرطان الثدي و مريضات الأورام الحميدة في الثدي. مجلة المجلس العربي للاختصاصات الصحية. 2020. مج. 21، ع. 1، ص ص. 28-37.
https://search.emarefa.net/detail/BIM-1272019
Data Type
Journal Articles
Language
Arabic
Notes
يتضمن مراجع ببليوجرافية : ص.36-37
Record ID
BIM-1272019