العلاقة بين الخطورة القلبية الوعائية و كثافة العظام لدى النساء بعد سن الإياس

Abstract EN

Objective: Several evidence has shown a link between osteoporosis and cardiovascular disease, where patients with bone fragility were found to have a greater risk of cardiovascular disease than patients with normal bone mass.

However, various studies conducted on this subject showed limited results, and animal studies have found a similarity in the mechanism between vascular calcification and the methods described for natural bone calcification, where a common expression of some proteins was discovered along with oxidative stress within both calcified vascular cells and bone cells.

Based on limited data, further studies were needed to confirm the presumed relationship between cardiovascular disease and bone density, as well as prospective studies on the potential role of osteoporosis in cardiovascular disease prevention.

Methods: We conducted a study at Damascus University, Al-Moawasat University Hospital in Damascus, Syria on women after the age of menopause in 2018-2019 to find out the extent of the correlation between these two factors.

The current study was based on a statistical analysis of 360 postmenopausal women with an average age of 61 years, who were screened for osteopenia or osteoporosis by a bone-density device.

Women with severe cardiovascular risk (138 women, 38.3%) and moderate cardiovascular risk (64 women, 17.8%) were compared with those who did not have cardiovascular risk (158 women, 43.9%).

The results of bone mineral density of the femoral neck and spine were classified into 3 groups according to WHO criteria: normal (-1.0 standard deviation), osteoporosis (between -1.0 and -2.5 standard deviations) and osteoporosis (more than -2.5 standard deviations).

Women with osteopenia or osteoporosis were grouped as low bone mass (LBM).

Results: The proportion of women with normal bone density was 39.5% (142 women) in the femoral neck, 21.1% (76 women) in the lumbar vertebrae, whereas we found lack of bone density (osteopenia) in 38.3% (138 women) in the femoral neck, 43.9% (158 women) in the lumbar spine, and osteoporosis was found in 22.2% (80 women) in the femoral neck, 35% (126 women) in lumbar vertebrae.

There were no statistically significant differences in the relationship between cardiovascular risk and bone density measurements of femoral neck (p-value=0.088), and the lumbar vertebrae (p-value=0.758), because both of them are greater than the significance level of 0.05.

Conclusions: Statistical analysis revealed that cardiovascular risk was an independent indicator of LBM in the femoral neck and lumbar spine.