الأهمية الإنذارية و العلاجية للواسم CD105 في سرطانة الثدي الغازية

Abstract EN

Background and Aim: Studies showed that even if a solid tumor possesses all of the genetic aberrations that are required for malignant transformation, it cannot enlarge beyond 1 to 2 mm in diameter unless it has the capacity to induce angiogenesis Angiogenesis is a complex multistep process required for tumor growth and metastasis.

It involves endothelial cell migration and proliferation, microvessel differentiation and anastomosis, and extracellular matrix remodeling.

We aimed to determine the prognostic value of marker CD105 in invasive breast carcinomas, its correlation with risk of lymph node metastasis and other clinicopathological factors such as: tumor size, grade, histologic type ,lymph node status, No of involved lymph nodes and percentage of KI67.

Materials and methods: evaluation of intratumoral microvessel density by using CD105 marker expression in tumor sections of patients with breast carcinoma in Al_Assad University Hospital.

Spearman's rho correlation was used to test the correlation between the immunohistochemical findings , conventional clinicopathological features and expression of markers.

Statistics software (SPSS, version 10.0; SPSS, Inc., Chicago, IL, USA) was used for all calculations.

Results:The count of CD105+microvessels proved to be valuable prognostic indicator which exhibited a predictive value stronger than tumor grade, histological type even in node negative patients.

No correlation was found between CD10 over expression and age,Tumour grade and histological type.

Conclusion: CD105 detection may be useful not only in terms of prognostic significance, but also in the potential selection of candidates who could benefit from specific antiangiogenic therapy with anti-CD105 antibodies