Toxicopathological evaluations of the ethanoic acid on liver tissues and blood parameters in albino rats
Other Title(s)
تقييم السمية المرضية لحمض الإيثانويك على أنسجة الكبد و مؤشرات الدم في الجرذان البيضاء
Joint Authors
Majid, Salimah Faraj
al-Shilabi, Aydah Miftah Abd al-Karim
Ahmidah, Ahmad Said H.
Source
Journal of Pure and Applied Sciences
Issue
Vol. 19, Issue 2 (30 Jun. 2020), pp.35-40, 6 p.
Publisher
Publication Date
2020-06-30
Country of Publication
Libya
No. of Pages
6
Main Subjects
Abstract EN
The liver is affected by hazardous substances, exhibiting different degrees of toxicity.
This study aimed to investigate the toxicopathological changes on liver tissues and blood parameters induced by ethanoic acid in rats.
Female rats (n = 20) were divided randomly into two groups of 10: a group 1, control group and group 2, treatment group which were oraly administered the ethanoic acid (EA) at a dose of 1 ml/kg/day (10 % EA).
Following fourteen days of treatment.
There were no significant changes in the mean values of MCH, MCV and PLT, on the other hand, a significant lower in the mean values of RBC, HCT and Hb.
Whereas, a significant increase in WBC, MCHC, AST and ALT were found in treated group when compared to control.
Furthermore, the treated group showed bi-nucleated and apoptotic nuclei hepatocytes, loss of hepatic architecture and dilated sinusoidal areas.
In conclusion EA consumption was found to have adverse effects on hepatic function in rats, hence the quantity of EA should be discouraged or reduced.
American Psychological Association (APA)
Majid, Salimah Faraj& al-Shilabi, Aydah Miftah Abd al-Karim& Ahmidah, Ahmad Said H.. 2020. Toxicopathological evaluations of the ethanoic acid on liver tissues and blood parameters in albino rats. Journal of Pure and Applied Sciences،Vol. 19, no. 2, pp.35-40.
https://search.emarefa.net/detail/BIM-1284989
Modern Language Association (MLA)
Majid, Salimah Faraj…[et al.]. Toxicopathological evaluations of the ethanoic acid on liver tissues and blood parameters in albino rats. Journal of Pure and Applied Sciences Vol. 19, no. 2 (2020), pp.35-40.
https://search.emarefa.net/detail/BIM-1284989
American Medical Association (AMA)
Majid, Salimah Faraj& al-Shilabi, Aydah Miftah Abd al-Karim& Ahmidah, Ahmad Said H.. Toxicopathological evaluations of the ethanoic acid on liver tissues and blood parameters in albino rats. Journal of Pure and Applied Sciences. 2020. Vol. 19, no. 2, pp.35-40.
https://search.emarefa.net/detail/BIM-1284989
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-1284989