Synthesis of the new derivative 1- diphenylamine enamine ascorbic Acid, and study of its biological activity
Other Title(s)
اصطناع المشتق الجديد1- ثنائي فينيل إينامين حمض الأسكوربيك و دراسة نشاطه البيولوجي
Parallel Title
اصطناع المشتق الجديد1- ثنائي فينيل إينامين حمض الأسكوربيك و دراسة نشاطه البيولوجي
Joint Authors
Shalar, Muhammad Mutazz Ghazi
Mirza, Jumah
Shriteh, Thana
Source
Journal of Natural Sciences, Life and Applied Sciences
Issue
Vol. 5, Issue 2 (30 Jun. 2021), pp.113-128, 16 p.
Publisher
Publication Date
2021-06-30
Country of Publication
Palestine (Gaza Strip)
No. of Pages
16
Main Subjects
Abstract EN
The new enamine [1- Diphenyl enamine ascorbic acid] has been prepared according to two methods: The first method was “The reaction between ascorbic acid and diphenylamine” has been done directly, however the yield was relatively low.
The second method was “the reaction between ascorbic acid and diphenylamine” which has been carried out through three steps: In the first step, the hydroxyl groups in (5, 6) position have been protected using the acetone, in the second step, the hydroxyl groups in (2, 3) position have been protected using iodide methyl.
The obtained compound (5, 6-dioxolan-2, 3-metoxy ascorbic acid) have been reacted with Diphenylamine to obtain the target molecule in the third step'' the structural determination has been confirmed using spectroscopy methods (FT-IR, 1H-NMR, 13C-NMR).
The target compound gave very good biological activity against Gram-positive bacteria (Staphylococcus Aureus) and Gram-negative (Pseudomonas Aeruginosa) bacteria, with Gentamicin as a reference active compound.
American Psychological Association (APA)
Shalar, Muhammad Mutazz Ghazi& Mirza, Jumah& Shriteh, Thana. 2021. Synthesis of the new derivative 1- diphenylamine enamine ascorbic Acid, and study of its biological activity. Journal of Natural Sciences, Life and Applied Sciences،Vol. 5, no. 2, pp.113-128.
https://search.emarefa.net/detail/BIM-1286967
Modern Language Association (MLA)
Shalar, Muhammad Mutazz Ghazi…[et al.]. Synthesis of the new derivative 1- diphenylamine enamine ascorbic Acid, and study of its biological activity. Journal of Natural Sciences, Life and Applied Sciences Vol. 5, no. 2 (Jun. 2021), pp.113-128.
https://search.emarefa.net/detail/BIM-1286967
American Medical Association (AMA)
Shalar, Muhammad Mutazz Ghazi& Mirza, Jumah& Shriteh, Thana. Synthesis of the new derivative 1- diphenylamine enamine ascorbic Acid, and study of its biological activity. Journal of Natural Sciences, Life and Applied Sciences. 2021. Vol. 5, no. 2, pp.113-128.
https://search.emarefa.net/detail/BIM-1286967
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-1286967