Synthesis of the new derivative 1- diphenylamine enamine ascorbic Acid, and study of its biological activity

Other Title(s)

اصطناع المشتق الجديد1- ثنائي فينيل إينامين حمض الأسكوربيك و دراسة نشاطه البيولوجي

Parallel Title

اصطناع المشتق الجديد1- ثنائي فينيل إينامين حمض الأسكوربيك و دراسة نشاطه البيولوجي

Joint Authors

Shalar, Muhammad Mutazz Ghazi
Mirza, Jumah
Shriteh, Thana

Source

Journal of Natural Sciences, Life and Applied Sciences

Issue

Vol. 5, Issue 2 (30 Jun. 2021), pp.113-128, 16 p.

Publisher

National Research Center

Publication Date

2021-06-30

Country of Publication

Palestine (Gaza Strip)

No. of Pages

16

Main Subjects

Biology

Abstract EN

The new enamine [1- Diphenyl enamine ascorbic acid] has been prepared according to two methods: The first method was “The reaction between ascorbic acid and diphenylamine” has been done directly, however the yield was relatively low.

The second method was “the reaction between ascorbic acid and diphenylamine” which has been carried out through three steps: In the first step, the hydroxyl groups in (5, 6) position have been protected using the acetone, in the second step, the hydroxyl groups in (2, 3) position have been protected using iodide methyl.

The obtained compound (5, 6-dioxolan-2, 3-metoxy ascorbic acid) have been reacted with Diphenylamine to obtain the target molecule in the third step'' the structural determination has been confirmed using spectroscopy methods (FT-IR, 1H-NMR, 13C-NMR).

The target compound gave very good biological activity against Gram-positive bacteria (Staphylococcus Aureus) and Gram-negative (Pseudomonas Aeruginosa) bacteria, with Gentamicin as a reference active compound.

American Psychological Association (APA)

Shalar, Muhammad Mutazz Ghazi& Mirza, Jumah& Shriteh, Thana. 2021. Synthesis of the new derivative 1- diphenylamine enamine ascorbic Acid, and study of its biological activity. Journal of Natural Sciences, Life and Applied Sciences،Vol. 5, no. 2, pp.113-128.
https://search.emarefa.net/detail/BIM-1286967

Modern Language Association (MLA)

Shriteh, Thana…[et al.]. Synthesis of the new derivative 1- diphenylamine enamine ascorbic Acid, and study of its biological activity. Journal of Natural Sciences, Life and Applied Sciences Vol. 5, no. 2 (Jun. 2021), pp.113-128.
https://search.emarefa.net/detail/BIM-1286967

American Medical Association (AMA)

Shalar, Muhammad Mutazz Ghazi& Mirza, Jumah& Shriteh, Thana. Synthesis of the new derivative 1- diphenylamine enamine ascorbic Acid, and study of its biological activity. Journal of Natural Sciences, Life and Applied Sciences. 2021. Vol. 5, no. 2, pp.113-128.
https://search.emarefa.net/detail/BIM-1286967

Data Type

Journal Articles

Language

English

Notes

Record ID

BIM-1286967