Synthesis and characterization of new β-lactam derivatve from sulfadiazine drug by many steps

Abstract EN

This research involved synthesis of new β-Lactam derivative from Azo compound[4-amino-N-(pyrimidine-2-yl)-3-(pyrimidine-2-yldiazenyl) benzene sulfonamide] (S1) record previously by many steps.

Starting conversion the free amino group in an azo comp.

to chloro acetamide derivative(S2), then reacted it with urea to give the oxazole ring derivative (S3) that which containing free amino group.

The condensation reaction between the amino group and P-bromobenzaldehyde to produce Shiff base (B14).

Finally staudinger's cyclo addition reaction go run between the Shiff base derivative (B14) and chloro acetyl chloride in the presence of tri ethyl amine (Et3N) as Base catalyst and dioxane as solvent at 5-10oC to give β-Lactam derivative (L14).

Most of these derivatives were confirmed by "FT-IR, 1HNMR and CNMR" spectra.