Solokap® (Herbaceutical formula) protect against fluvastatin-induced hepatitis by ameliorating oxidative stress and inflammation in female albino rats
Joint Authors
Salama, Afrah F.
al-Said, Karim S.
Tusun, Ihab M.
Muhammad, Amr E.
Source
Alexandria Journal of Veterinary Sciences
Issue
Vol. 62, Issue 1 (31 Jul. 2019), pp.89-101, 13 p.
Publisher
Alexandria University Faculty of Veterinary Medicine
Publication Date
2019-07-31
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
High doses of Fluvastatin (F) insure liver cells toxicity in hepatocytes function and homeostasis.
This study investigated the possible therapeutic effect of solokap (S) on hepatitis induced by F in female rats.
Animals were divided into four groups: group1 (negative control), group2 (F-control), group3, received solokap (S) only and group 4(F+S).
Rats were received F for first 10 days.
Results obtained showed that F increased alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AlP), gamma glutamyl transpeptidase (γ-GTP), total bilirubin, malondialdhyde (MDA), tumor necrosis factor α protein (TNFα), tumor growth factorβ1 (TGFβ1), nuclear factor Kappa B (NFKB), cyclooxygenase-1 and 2 (COX-1 and 2), while, decreased the levels of albumin and total protein, reduced glutathione (GSH), Glutathione peroxidase (GPx), catalase (CAT) and interleukin-10 protein (IL-10).
Liver histological and immune-histochemical investigations of rats administered F showed sever congestion in portal vein associated with fibrosis and inflammatory cells infiltration.
Also, collagen-I stained cells were found in the portal area and the central vein.
On the other hand, animals treated with solokap showed improvements for these parameters as well as in the histological and immune-histochemical feature of the liver.
Therefore, the present results revealed that Solokap could minimize the toxic effects of Fluvastatin.
American Psychological Association (APA)
Salama, Afrah F.& al-Said, Karim S.& Tusun, Ihab M.& Muhammad, Amr E.. 2019. Solokap® (Herbaceutical formula) protect against fluvastatin-induced hepatitis by ameliorating oxidative stress and inflammation in female albino rats. Alexandria Journal of Veterinary Sciences،Vol. 62, no. 1, pp.89-101.
https://search.emarefa.net/detail/BIM-1323523
Modern Language Association (MLA)
Salama, Afrah F.…[et al.]. Solokap® (Herbaceutical formula) protect against fluvastatin-induced hepatitis by ameliorating oxidative stress and inflammation in female albino rats. Alexandria Journal of Veterinary Sciences Vol. 62, no. 1 (Jul. 2019), pp.89-101.
https://search.emarefa.net/detail/BIM-1323523
American Medical Association (AMA)
Salama, Afrah F.& al-Said, Karim S.& Tusun, Ihab M.& Muhammad, Amr E.. Solokap® (Herbaceutical formula) protect against fluvastatin-induced hepatitis by ameliorating oxidative stress and inflammation in female albino rats. Alexandria Journal of Veterinary Sciences. 2019. Vol. 62, no. 1, pp.89-101.
https://search.emarefa.net/detail/BIM-1323523
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 99-101
Record ID
BIM-1323523