Alteration of renal cytokines (TNF-α, Cox-2, caspase-3, Bcl-2, and CD95)‎ by E102 food dye administration in male mice : possible immune modulation by vitamin E

Other Title(s)

تغيير السيتوكينات الكلوية (Bcl-2 ،caspase-3 ،Cox-2 ،TNF-α و (CD95عن طريق تعاطي صبغة الطعام E102 في ذكور الفئران : التأثير المناعي المحتمل لفيتامين ه

Joint Authors

al-Shaykh, Turki Mubarak Hamdan
al-Shirbini, Sali Abd al-Hakim
Ibrahim, Amal Atiyah al-Mursi

Source

Journal of the North for Basic and Applied Sciences

Issue

Vol. 6, Issue 2 (30 Nov. 2021), pp.89-100, 12 p.

Publisher

Northern Border University Scientific Publishing Center

Publication Date

2021-11-30

Country of Publication

Saudi Arabia

No. of Pages

12

Main Subjects

Biology

Abstract EN

-This could be considered first study that concerned with evaluation of the immunomodulatory effect of vitamin E (vit E) against renal cytokines alteration induced by synthetic food dyes in male mice.

Mice were divided into 4 groups; mice in group 1 were the control, animals in group 2 received vit E (100mg/kg bw), group 3 mice administered E102 (300mg/kg bw), and mice from group 4 received E102+vit E for 28 days.

Nephrotoxicity in mice was confirmed by assessing changes in levels of the renal markers and antioxidant status.

Co-administration of vit E resulted in restoration of altered levels of renal functions (electrolytes, creatinine & urea), antioxidants status and different cytokines (TNF-α, Cox-2, caspase-3, Bcl-2, and CD95).

The therapeutic role of vit E against E102 food dye-induced nephrotoxicity could be attributed to their antioxidant effects and free radical scavenging properties.

American Psychological Association (APA)

Ibrahim, Amal Atiyah al-Mursi& al-Shaykh, Turki Mubarak Hamdan& al-Shirbini, Sali Abd al-Hakim. 2021. Alteration of renal cytokines (TNF-α, Cox-2, caspase-3, Bcl-2, and CD95) by E102 food dye administration in male mice : possible immune modulation by vitamin E. Journal of the North for Basic and Applied Sciences،Vol. 6, no. 2, pp.89-100.
https://search.emarefa.net/detail/BIM-1340992

Modern Language Association (MLA)

Ibrahim, Amal Atiyah al-Mursi…[et al.]. Alteration of renal cytokines (TNF-α, Cox-2, caspase-3, Bcl-2, and CD95) by E102 food dye administration in male mice : possible immune modulation by vitamin E. Journal of the North for Basic and Applied Sciences Vol. 6, no. 2 (Nov. 2021), pp.89-100.
https://search.emarefa.net/detail/BIM-1340992

American Medical Association (AMA)

Ibrahim, Amal Atiyah al-Mursi& al-Shaykh, Turki Mubarak Hamdan& al-Shirbini, Sali Abd al-Hakim. Alteration of renal cytokines (TNF-α, Cox-2, caspase-3, Bcl-2, and CD95) by E102 food dye administration in male mice : possible immune modulation by vitamin E. Journal of the North for Basic and Applied Sciences. 2021. Vol. 6, no. 2, pp.89-100.
https://search.emarefa.net/detail/BIM-1340992

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 98-100

Record ID

BIM-1340992