دراسة تأثير مشاركة مضادات البيتا لاكتام و الأمينو غلوكوزيدات مع مجموعات أخرى من المضادات الحيوية و دراسة التأثير التأزري لهذه المضادات

Abstract EN

Objective : This study aimed to evaluate the effect of antibiotic combination between beta-lactams and aminoglycosids with another group of antibiotics.

Methods : Fifty isolates of Pseudomonas aeruginosa were identified using different microscopic, cultural characteristics and biochemical tests.

Eight isolates (16 %) were from burn infections, 20 (40 %) from urinary tract infections, 16 (32 %) from burn infections and 6 (12 %) from otitis media cases.

Antimicrobial susceptibility tests and minimal inhibitory concentration MIC were performed.

Results : Pseudomonas aeruginosa exhibited (100 %) resistance to amoxicillin, amoxicillin/clavulanic acid and cefazolin.

While percentages of resistance to carbenicillin, cefotaxime and ceftazidime were (84 %), (80 %) and (78 %) respectively.

Resistance percentages to gentamycin, tobramycin, piperacillin, amikacin and ciprofloxacin were (52 %), (26 %), (24 %), (6 %) and (4 %) respectively.

All isolates of Pseudomonas aeruginosa were highly sensitive (100 %) to aztreonam, cefepime, imipenem, peofloxacin and ofloxacin.

Combinations of ciprofloxacin with gentamycin and ceftazidime gave interesting results against the local bacterial isolates in reducing their MIC values.

Gentamycin and ceftazidime gave an obvious decrease in MIC values after combination of these drugs and used against Pseudomonas aeruginosa.

Conclusions : The study shows that the combination of beta-lactams and aminoglycosids with ciprofloxacin is highly effective in treatment of Pseudomonas aeruginosa infections.