Studying of the transdermal absorption of metformin hydrochloride via novel none ionic microemulsions

Other Title(s)

دراسة الامتصاص الجلدي ل المتفورمين هيدروكلورايد باستخدام مستحلبات دقيقة جديدة غير متأينة

Dissertant

al-Hiyali, Aminah Wamid Abd al-Jabbar

Thesis advisor

al-Krad, Jamal al-Yusuf

University

Isra University

Faculty

Faculty of Pharmacy

University Country

Jordan

Degree

Master

Degree Date

2021

English Abstract

Metformin is an antidiabetic drug.

It is used for the treatment of non-insulin-dependent diabetes.

It has a low bioavailability and many side effects associated with oral application such as gastric irritation.

In this study, non-ionic surfactants were used to produce and characterize seven microemulsions (MEs) containing Metformin HCL for oral and transdermal application.

The MEs were characterized regarding their droplet size, poly disparity index, rheological properties, the flux through rat’s skin, and in vivo bioavailability in rats.

The results showed that MEs had colloidal properties.

The droplet size was below 100 nm and the MEs had ideal viscosity (Newtonian viscosity).

Besides, the in vitro bioavailability using Franz diffusion cells through the skin over 24 h showed a flux as high as 0.08178 mg/cm2 .hr.

Moreover, the oral in vivo and transdermal bioavailability in rats was higher than of the oral solution.

The developed formulations are nonionic loaded metformin can be an ideal carrier and promising formulations for transdermal administration of Metformin HCL.

Main Subjects

Pharmacology

No. of Pages

52

Table of Contents

Table of contents.

Abstract.

Abstract in Arabic.

Chapter One : Introduction.

Chapter Two : Previous studies about transdermal application and development of the MEs formulation for metformin.

Chapter Three : Materials, instruments and methods.

Chapter Four : Results.

Chapter Five : Discussion.

Chapter Six : Conclusion and recommendations.

References.

American Psychological Association (APA)

al-Hiyali, Aminah Wamid Abd al-Jabbar. (2021). Studying of the transdermal absorption of metformin hydrochloride via novel none ionic microemulsions. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-1353001

Modern Language Association (MLA)

al-Hiyali, Aminah Wamid Abd al-Jabbar. Studying of the transdermal absorption of metformin hydrochloride via novel none ionic microemulsions. (Master's theses Theses and Dissertations Master). Isra University. (2021).
https://search.emarefa.net/detail/BIM-1353001

American Medical Association (AMA)

al-Hiyali, Aminah Wamid Abd al-Jabbar. (2021). Studying of the transdermal absorption of metformin hydrochloride via novel none ionic microemulsions. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-1353001

Language

English

Data Type

Arab Theses

Record ID

BIM-1353001