The clinical presentations and outcomes in a cohort of hospitalized elderly covid-19 Egyptian patients : a cross-sectional study

Abstract EN

Background and aims: Elders at an increased risk of getting the novel COVID-19 infection.

Materials and Methods: We analyzed the clinical presentations, laboratory and radiological investigations, and the patient’s outcome in fifty seniors aged 60 years and more who were hospitalized due to COVID-19 infection in the period from December 2020 till March 2021.

Results: The mean age was 68.2 ± 5.9 years (60% males and 40% females), 70% with comorbidities.

Our patients exhibited a variety of clinical manifestations (constitutional, respiratory, gastrointestinal, and atypical) and hematological presentations with variable percentages.

The mean period of hospital stay was15.05 days with 60% of the patients cured and 40% died (60% males, 40% females).

The causes of death were septic shock (81.8%), ARDS (36.3%), AKI (18.2%), DIC (13.6), and encephalitis (9.1%).

Using multivariant regression analysis and Roc curve analysis; levels of D-dimer >901ng/ml, interleukin-6 >13.5pg/ml, and >30% lung involvement were independent predictors of mortality after adjustment of other predictors.

Conclusion: Elderly patients are vulnerable to complications caused by SARS Cov-2 infection especially in the setting of multiple comorbidities.

Unexpectedly, gastrointestinal manifestations were associated with mortality in seniors along with low oxygen saturation, and wheezy chest.

After multivariant regression analysis only D-dimer, interleukin-6, and the degree of lung involvement in CT were independent predictors of mortality in seniors after adjustment of other predictors