Synthesis, in vitro antimicrobial assay and molecular docking studies of some new symmetrical Bis-Schiff Bases and their 2-Azetidinones

Joint Authors

Abd Allah, Midya Nuri
Hasan, Sanjar Ali
Aziz, Dara Muhammad

Source

ZANCO Journal of Pure and Applied Sciences

Issue

Vol. 33, Issue 2 (30 Apr. 2021), pp.34-50, 17 p.

Publisher

Salahaddin University-Erbil Department of Scientific Publications

Publication Date

2021-04-30

Country of Publication

Iraq

No. of Pages

17

Main Subjects

Chemistry

Abstract EN

Four membered cyclic amides that are a broadly utilized class of antimicrobial agents up to now.

Moreover, Symmetrical Bis-Schiff bases constitute an extraordinary class of strained compounds with varied applications and building blocks for the synthesis of 2-Azetidinones antibiotics.

Because of those over biological significance, this study concludes a versatile synthetic precursor for the synthesis of the new Symmetrical Bis-Schiff bases and 2-Azetidinones in an exceedingly high yield.

2-Azetidinones were synthesized through [2+2] dichloroketene-imine cycloaddition reaction.

The structures of the synthesized compounds were characterized by FT-IR, 1H-NMR, and 13C-NMR.

Additionally, the products were assayed against two antibacterial types Gram-positive (S.

aureus) and Gram-negative (E.

coli) microorganisms and two varieties of fungal strains A.

niger, T.

mentagrophytes by broth microdilution method.

As a result, all synthesized compounds displayed good antimicrobial activities against resistant strains.

Finally, molecular docking studies were explained the inhibitory activities for the new products with the target (PDB ID: 1MWU) methicillin acyl-Penicillin binding protein 2a from methicillin-resistant Staphylococcus aureus strain 27r at 2.60 Å resolution.

American Psychological Association (APA)

Hasan, Sanjar Ali& Abd Allah, Midya Nuri& Aziz, Dara Muhammad. 2021. Synthesis, in vitro antimicrobial assay and molecular docking studies of some new symmetrical Bis-Schiff Bases and their 2-Azetidinones. ZANCO Journal of Pure and Applied Sciences،Vol. 33, no. 2, pp.34-50.
https://search.emarefa.net/detail/BIM-1388132

Modern Language Association (MLA)

Hasan, Sanjar Ali…[et al.]. Synthesis, in vitro antimicrobial assay and molecular docking studies of some new symmetrical Bis-Schiff Bases and their 2-Azetidinones. ZANCO Journal of Pure and Applied Sciences Vol. 33, no. 2 (2021), pp.34-50.
https://search.emarefa.net/detail/BIM-1388132

American Medical Association (AMA)

Hasan, Sanjar Ali& Abd Allah, Midya Nuri& Aziz, Dara Muhammad. Synthesis, in vitro antimicrobial assay and molecular docking studies of some new symmetrical Bis-Schiff Bases and their 2-Azetidinones. ZANCO Journal of Pure and Applied Sciences. 2021. Vol. 33, no. 2, pp.34-50.
https://search.emarefa.net/detail/BIM-1388132

Data Type

Journal Articles

Language

English

Notes

Includes appendix : p. 48-50

Record ID

BIM-1388132