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القيمة المهملة للموارد الطبيعية الإماراتية : الأنشطة الفريدة المضادة للسرطان من نبات المانغروف الإماراتي
Other Title(s)
The neglected value of Emirati natural resources : the unique anti-cancer activities of Emirati mangroves
Author
Source
Issue
Vol. 20, Issue 2 (31 Dec. 2021), pp.1-11, 11 p.
Publisher
Rashid Ben Humaid Award for Culture and Science
Publication Date
2021-12-31
Country of Publication
United Arab Emirates
No. of Pages
11
Main Subjects
Abstract EN
Background.
The increased mortality rate due to cancer, the dangerous side effects of available anti-cancer drugs and the resistance of cancer to current drugs, have led to an urgent need to discover new anti cancer drugs.
Plants are known as one of the main sources of medicines.
Mangroves are one of the oldest trees known for many years in folklores in the treatment of many diseases including cancer.
The mangrove plant is one of the most common tree species in terms of its adaptation to adverse environmental conditions in the UAE.
Purpose.
The main objective of this study is to explore the anti-cancer activity, and the degree of specificity and safety of the Emirati mangrove plant through a comparison of different extracts from different parts of the plant on different cancer cells.
Methodology.
The leaves and stems of the plant were collected from the Sharjah desert and dried in the shade.
The dried leaves and stems were ground and extracted with ethanol.
The ethanol extract was dried and fractionated using different organic solvents including hexane, dichloromethane, ethyl acetate and methanol.
Then each dried extract was tested on different cancer cells, including breast cancer (MDA-231), colon cancer (HT29), lung cancer (A549) and normal cells as a source of comparison.
Then the anticancer activities of all extracts were compared.
Results.
Both the leaves and stems under investigation showed variable anti-cancer activities.
However, hexane and methanol extracts from the leaves were the safest on normal cells.
On the other hand, hexane extract from leaves caused non-selective anti-cancer activities, while methanol extract from leaves caused selective inhibitory activities, especially against breast cancer (MDA-231).
Conclusions.
The results obtained indicated that hexane and methanol extracts from mangrove leaves could be pioneering new sources of safe and effective anti-cancer drugs.
American Psychological Association (APA)
سامح سليمان. 2021. القيمة المهملة للموارد الطبيعية الإماراتية : الأنشطة الفريدة المضادة للسرطان من نبات المانغروف الإماراتي. مجلة عجمان للدراسات و البحوث،مج. 20، ع. 2، ص ص. 1-11.
https://search.emarefa.net/detail/BIM-1404727
Modern Language Association (MLA)
سامح سليمان. القيمة المهملة للموارد الطبيعية الإماراتية : الأنشطة الفريدة المضادة للسرطان من نبات المانغروف الإماراتي. مجلة عجمان للدراسات و البحوث مج. 20، ع. 2 (2021)، ص ص. 1-11.
https://search.emarefa.net/detail/BIM-1404727
American Medical Association (AMA)
سامح سليمان. القيمة المهملة للموارد الطبيعية الإماراتية : الأنشطة الفريدة المضادة للسرطان من نبات المانغروف الإماراتي. مجلة عجمان للدراسات و البحوث. 2021. مج. 20، ع. 2، ص ص. 1-11.
https://search.emarefa.net/detail/BIM-1404727
Data Type
Journal Articles
Language
Arabic
Notes
يتضمن مراجع ببليوجرافية : ص. 9-11
Record ID
BIM-1404727