Determination of synergistic effects of antibiotics and Zno NPs against isolated E. Coli and A. Baumannii bacterial strains from clinical samples
Joint Authors
al-Sharif, Fadwa Ubayd Sulayman
al-Barraq, Ahmad Muhammad
al-Qublan, Dina K.
Mateen, Aishah
Source
Saudi Journal of Biological Sciences
Issue
Vol. 28, Issue 9 (30 Sep. 2021), pp.5332-5337, 6 p.
Publisher
Publication Date
2021-09-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Abstract EN
The mortality rates has been increased globally due to multidrug resistant (MDR) E.coli and A.baumanii bacterial strains and also there is an emerging resistance of the Enterobacteriaceae family of bacteria to Carbapenem antibiotics (CRE) in Saudi Arabia.
The main aim of our research study is to isolate E.coli and A.
baumannii bacterial species from various collected clinical samples and to evaluate the MIC and FICI of Colistin, Ciprofloxacin, Meropenem and ZnO NPs and in combination of Colistin, Ciprofloxacin, Meropenem with ZnO NPs.
The clinical isolated strains of A.
baumannii (MRO-17-13) and A.
baumannii (MRO-17-25) was found to be sensitive towards colistin with 0.5 μg/mL concentration, whereas, all the isolated A.
baumannii strains showed similar MIC value 2 mg/mL when tested with ZnO NPs, the MIC value for the ZnO NPs was found to be similar for all the E.coli strains 0.25 mg/mL.
The effects of all Ciprofloxacin concentrations used in the study were bacteriostatic against E.
coli (01UR19006568-01) strain but 1 mg/mL concentration of ZnO NPs alone is showed bactericidal activity, ZnO NPs effect was found to be concentration dependent, as highest concentration of ZnO NPs showed strongest antibacterial effect.
In conclusion, more investigation is required to evaluate the acceptable concentration of Zno NPs and antibiotics selected to avoid toxicity and must be tested against more clinically isolated gram-negative bacterial strains.
American Psychological Association (APA)
al-Sharif, Fadwa Ubayd Sulayman& al-Barraq, Ahmad Muhammad& al-Qublan, Dina K.& Mateen, Aishah. 2021. Determination of synergistic effects of antibiotics and Zno NPs against isolated E. Coli and A. Baumannii bacterial strains from clinical samples. Saudi Journal of Biological Sciences،Vol. 28, no. 9, pp.5332-5337.
https://search.emarefa.net/detail/BIM-1411368
Modern Language Association (MLA)
al-Barraq, Ahmad Muhammad…[et al.]. Determination of synergistic effects of antibiotics and Zno NPs against isolated E. Coli and A. Baumannii bacterial strains from clinical samples. Saudi Journal of Biological Sciences Vol. 28, no. 9 (2021), pp.5332-5337.
https://search.emarefa.net/detail/BIM-1411368
American Medical Association (AMA)
al-Sharif, Fadwa Ubayd Sulayman& al-Barraq, Ahmad Muhammad& al-Qublan, Dina K.& Mateen, Aishah. Determination of synergistic effects of antibiotics and Zno NPs against isolated E. Coli and A. Baumannii bacterial strains from clinical samples. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 9, pp.5332-5337.
https://search.emarefa.net/detail/BIM-1411368
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5337
Record ID
BIM-1411368