Murine liver response to allium sativum treatment during infection induced-trypanosomiasis

Joint Authors

al-Azzuni, Ahmad S.
al-Shuaybi, Isam M.
Dakhil, Muhammad A.
Khalil, Muna
al-Qurayshi, Salih

Source

Saudi Journal of Biological Sciences

Issue

Vol. 28, Issue 6 (30 Jun. 2021), pp.3270-3274, 5 p.

Publisher

Saudi Biological Society

Publication Date

2021-06-30

Country of Publication

Saudi Arabia

No. of Pages

5

Main Subjects

Agriculture

Abstract EN

Hepatic injury induced by trypanosomiasis is one of the major health problems not only to human but also to wild and domestic animals.

This study aimed to evaluate the hepatoprotective role of Allium sativum extract (ASE) against Trypanosoma evansi infection in mice.

Animals were divided into 4 groups.

Group I received only saline while group II received ASE (20 mg/Kg).

Animals of group III and group IV were infected with T.

evansi.

The latter group was treated with ASE.

The infrared spectroscopic analysis of A.

sativum extract exhibited bands between 3700 cm_1 and 599 cm_1.

On day 4 post T.

evansi infection, ASE decreased the parasitemia by about 15 fold.

Also, ASE regulated the number of erythrocytes and leucocytes and the hemoglobin content.

In addition, the histopathological damage was reduced after treatment with ASE.

Moreover, the oxidant and the antioxidant markers (glutathione, malondialdehyde and catalase) were regulated in the infected-treated animals.

Collectively, the results proved the protective role of ASE against T.

evansi infection in mice.

American Psychological Association (APA)

Dakhil, Muhammad A.& al-Shuaybi, Isam M.& al-Azzuni, Ahmad S.& al-Qurayshi, Salih& Khalil, Muna. 2021. Murine liver response to allium sativum treatment during infection induced-trypanosomiasis. Saudi Journal of Biological Sciences،Vol. 28, no. 6, pp.3270-3274.
https://search.emarefa.net/detail/BIM-1415245

Modern Language Association (MLA)

Dakhil, Muhammad A.…[et al.]. Murine liver response to allium sativum treatment during infection induced-trypanosomiasis. Saudi Journal of Biological Sciences Vol. 28, no. 6 (2021), pp.3270-3274.
https://search.emarefa.net/detail/BIM-1415245

American Medical Association (AMA)

Dakhil, Muhammad A.& al-Shuaybi, Isam M.& al-Azzuni, Ahmad S.& al-Qurayshi, Salih& Khalil, Muna. Murine liver response to allium sativum treatment during infection induced-trypanosomiasis. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 6, pp.3270-3274.
https://search.emarefa.net/detail/BIM-1415245

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 3273-3274

Record ID

BIM-1415245