استخدام تقنية التجفيد من أجل تحضيرجسيمات دقيقة ملبسة معويا من السفاسالازين
Other Title(s)
The use of freeze drying technology for preparing enteric microparticles of Sulfasalazine
Joint Authors
Source
المجلة العربية للعلوم الصيدلية
Issue
Vol. 6, Issue 3 (31 May. 2020), pp.11-20, 10 p.
Publisher
Publication Date
2020-05-31
Country of Publication
Syria
No. of Pages
10
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Freeze drying (FD) has gained more importance as a method for preparing coated microparticles.
This study aimed to prepare and to investigate the characteristics of enteric sulfasalazine- loaded microparticles (MP) prepared by freeze drying (FD) method.
particle size distribution, residual moisture, differential scanning calometry (DSC), drug release profiles, yield, and encapsulation rate were studied.
Sulfasalazine (SSZ) was lyophilized with sucrose, lactose, mannitol (stabilizers), Eudragit (Eud S100) (gastro-resistant coating agent), hydroxyl propyl methyl cellulose (HPMC) (plasticizer) and polysorpate as a surfactant in aqueous disperstions.
MP produced by FD had a median size about 8.5 μm, the moisture content was 2.2%.
DSC diagrams showed an absence of the drug peak, which may refer to its encapsulation.
SSZ release profile showed little drug release in the simulated stomach medium 5.2%, after 3 hours, whereas it gave high release in the simulated intestine medium equal to 91.3% in the same period of time.
the yield of the process was about 86% and the encapsulation efficiency (EE) was 90%.
our results confirmed that the freeze drying technique is one of the good methods used to produce enteric microparticles.
American Psychological Association (APA)
الحسين، باسل واللحام، أنطون. 2020. استخدام تقنية التجفيد من أجل تحضيرجسيمات دقيقة ملبسة معويا من السفاسالازين. المجلة العربية للعلوم الصيدلية،مج. 6، ع. 3، ص ص. 11-20.
https://search.emarefa.net/detail/BIM-1424223
Modern Language Association (MLA)
الحسين، باسل واللحام، أنطون. استخدام تقنية التجفيد من أجل تحضيرجسيمات دقيقة ملبسة معويا من السفاسالازين. المجلة العربية للعلوم الصيدلية مج. 6، ع. 3 (أيار 2020)، ص ص. 11-20.
https://search.emarefa.net/detail/BIM-1424223
American Medical Association (AMA)
الحسين، باسل واللحام، أنطون. استخدام تقنية التجفيد من أجل تحضيرجسيمات دقيقة ملبسة معويا من السفاسالازين. المجلة العربية للعلوم الصيدلية. 2020. مج. 6، ع. 3، ص ص. 11-20.
https://search.emarefa.net/detail/BIM-1424223
Data Type
Journal Articles
Language
Arabic
Notes
يتضمن مراجع ببليوجرافية : ص. 19-20
Record ID
BIM-1424223