اصطناع سريع و نظيف لبعض مشتقات أساس مانيخ من تفاعل N- هيدروكسي متيل فتال إيميد مع مركبات أمينوبيريدين المختلفة و تقييم فعاليتها الحيوية

Abstract EN

This study includes a synthesis of two of Mannich bases, these compounds are : N-[(2-pyridyl) aminomethyl] phthalimide, N-[(4-Methyl-2-pyridyl)- aminomethyl] phthalimide derived from reaction of N-hydroxymethyl- phthalimide with different aminopyridines, by using a simple, rapid and clean method.

the products then were compared with the ones prepared by conventional method (refluxing in solvent).

the prepared compounds were characterized by FT-IR and LC-MS spectra.

All compounds were also evaluated for their biological activity in vitro against Gram-positive bacteria staphylococcus epidermidis and fungi candida albicans.