Evaluation of fine-needle aspiration cytology (FNAC) sensitivity compared to PCR for diagnosing tuberculosis lymphadenitis
Joint Authors
Muhammad, Abd al-Munim
Mustafa, Umar
Muhammad, Ibtihal
Abd al-Majid, Shayma
Hasan, Nafisah
Khalil, Mayadah
Sulayman, Najiyah
Aly, Alaa
Umar, Ahmad
Source
Sudan Journal of Medical Sciences
Issue
Vol. 17, Issue 3 (30 Sep. 2022), pp.330-340, 11 p.
Publisher
Omdurman Islamic University Faculty of Medicine
Publication Date
2022-09-30
Country of Publication
Sudan
No. of Pages
11
Main Subjects
Abstract EN
Background: Tuberculosis (TB) is a major healthcare burden in Sudan and other developing countries, it is considered the second most common cause of death from infectious diseases after those due to AIDS.
In Sudan, TB lymphadenitis (TBLA) remains one of the major health problems.
This descriptive cross-sectional study was conducted at the University of Medical Sciences and Technology (UMST) and Total Labcare Diagnostic Center (TDC).
The study aims to compare the sensitivity of Fine Needle Aspiration Cytology (FNAC) smears with that of the Polymerase Chain Reaction (PCR) for the diagnosis of TBLA.
Methods: Fifty-five dry smears were obtained using fine-needle aspiration (FNA) from an enlarged lymph node.
PCR was applied to detect the target gene (IS6110).
May-Grunwald-Giemsa (MGG) or Diff quick stains were used.
Results: Two (4%) patients with TBLA were non-necrotic, while fifty-three of them (96%) were necrotic.
Moreover, 17 (30%) fine-needle lymph node aspiration specimens were confirmed by PCR to be positive for Mycobacterium tuberculosis complex (MTB complex) while 38 (70%) of them were negative.
Conclusion: There was no significant difference between the sensitivity of PCR and that of FNAC (P-value = 0.33).
American Psychological Association (APA)
Mustafa, Umar& Muhammad, Ibtihal& Umar, Ahmad& Muhammad, Abd al-Munim& Abd al-Majid, Shayma& Aly, Alaa…[et al.]. 2022. Evaluation of fine-needle aspiration cytology (FNAC) sensitivity compared to PCR for diagnosing tuberculosis lymphadenitis. Sudan Journal of Medical Sciences،Vol. 17, no. 3, pp.330-340.
https://search.emarefa.net/detail/BIM-1429820
Modern Language Association (MLA)
Aly, Alaa…[et al.]. Evaluation of fine-needle aspiration cytology (FNAC) sensitivity compared to PCR for diagnosing tuberculosis lymphadenitis. Sudan Journal of Medical Sciences Vol. 17, no. 3 (2022), pp.330-340.
https://search.emarefa.net/detail/BIM-1429820
American Medical Association (AMA)
Mustafa, Umar& Muhammad, Ibtihal& Umar, Ahmad& Muhammad, Abd al-Munim& Abd al-Majid, Shayma& Aly, Alaa…[et al.]. Evaluation of fine-needle aspiration cytology (FNAC) sensitivity compared to PCR for diagnosing tuberculosis lymphadenitis. Sudan Journal of Medical Sciences. 2022. Vol. 17, no. 3, pp.330-340.
https://search.emarefa.net/detail/BIM-1429820
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 338-340
Record ID
BIM-1429820