الإمراضيات الحملية بعد قصة إجهاض

Abstract EN

Background & Aim: The research aims to study the relationship between miscarriages history and the risk of placental dysfunction disorders including preeclampsia, stillbirth, Small for gestational age (SGA), intrauterine growth restriction (IUGR), placental abruption, and spontaneous preterm birth.

Materials and Methods: A Prospective Cross-Sectional Study, conducted in the Obstetrics and Gynecology University Hospital at Damascus from 29/7/2020 to 29/7/2021, included 800 primiparous women (400 haven't a prior miscarriage, 308 have a one prior miscarriages, 57 have two prior miscarriages, 35 have three or more prior miscarriages).

- Results: Compared with women with no prior miscarriage, women with 1, 2, 3 or more prior miscarriage had an increased Odds ratios of each of gestational diabetes (OR 1.1, 1.2, 1.5, respectively) and gestational hypertension (OR 1.1, 1.5, 2.1, respectively), preeclampsia / eclampsia (OR 1.2, 1.6, 2.1, respectively), preterm placental abruption (OR 1.7, 3.1, 3.4 respectively) , term placental abruption (OR 1.6, 1.4, 3.7, respectively), spontaneous preterm birth (OR 1.5, 1.8, 2.3, respectively), cesarean delivery (OR 1.2, 1.8, 4, respectively), IUGR (OR 1.8, 2.4, 2.6, respectively), SGA (OR 1.6, 1.7, 2.9, respectively), and stillbirth (OR 1.8, 3.3, 5.6, respectively), but the relationship was statistically significant between the increase in the prior miscarriage number and each of the increased pregnant woman age, cesarean delivery, decreased mean fetal / newborn weight, the stillbirth and the newborn's need an incubator.

Conclusions: History of one or more prior miscarriage is associated with an increased risk of comorbidities in subsequent pregnancy and should be regarded as a risk factor in antenatal care.