The unified approach of ionizing radiation on biological matter : action of heavy charged particles on mammalian cells
Author
Source
Scientific Journal for the Faculty of Science-Sirte University
Issue
Vol. 2, Issue 1 (30 Apr. 2022), pp.106-110, 5 p.
Publisher
Sirte University Faculty of Science
Publication Date
2022-04-30
Country of Publication
Libya
No. of Pages
5
Main Subjects
Abstract EN
Damaging effects to mammalian cells by heavy charged particles have been realized in terms of the mean free path for linear primary ionization (the spacing of ionizing events along the charged particle tracks) using in vitro radiobiological experimentation data.
Damage is found to be optimum when the mean free path for linear primary ionization along the tracks in the cell nucleus matches the mean chord length of approximately 1.8 nm through a DNA segment.
A simple semi-theoretical model is proposed to define absolute biological effectiveness based on effect inactivation cross section s (mm2) which is interrelated to the mean free path for linear primary ionization l.
For heavy charged particles, the model shows a saturation region for the effect cross section, ss = 60 mm2 for l ≤ 1.8 nm.
The model explains the mechanisms leading to cell death via DNA strand scissions.
In the saturation region, double strand breaks of the DNA are predominant, unrepaired or mismatched repair processes lead to maximum damage.
At higher mean free path; l > 1.8 nm, single strand breaks of the DNA is the main basic mechanism and thus repairable processes are possible.
American Psychological Association (APA)
al-Kharam, Ali S.. 2022. The unified approach of ionizing radiation on biological matter : action of heavy charged particles on mammalian cells. Scientific Journal for the Faculty of Science-Sirte University،Vol. 2, no. 1, pp.106-110.
https://search.emarefa.net/detail/BIM-1440051
Modern Language Association (MLA)
al-Kharam, Ali S.. The unified approach of ionizing radiation on biological matter : action of heavy charged particles on mammalian cells. Scientific Journal for the Faculty of Science-Sirte University Vol. 2, no. 1 (Apr. 2022), pp.106-110.
https://search.emarefa.net/detail/BIM-1440051
American Medical Association (AMA)
al-Kharam, Ali S.. The unified approach of ionizing radiation on biological matter : action of heavy charged particles on mammalian cells. Scientific Journal for the Faculty of Science-Sirte University. 2022. Vol. 2, no. 1, pp.106-110.
https://search.emarefa.net/detail/BIM-1440051
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 109-110
Record ID
BIM-1440051