نسبة الريزيستين إلى الأديبونيكتين بوصف عاملاً تنبؤياً بمقاومة الأنسولين و عوامل الأختطار القلبية الوعائية الإستقلابية و الإلتهابية عند عينة من السوريين المصابين بالنمط الثاني من الداء السكري

Abstract EN

Background : Globally, diabetes and its cardiovascular complications contribute to a large number of morbidities and deaths.

Still, hypotheses explaining the association between type 2 of this disease and both obesity and cardiovascular complications are insufficient to enable us to avoid these complications.

Adipose tissue secretes many signal proteins that contribute to the control of many metabolic and inflammatory aspects in the body, including adiponectin and resistin.

Their opposite actions towards insulin functions suggest their potential contribution to insulin resistance, diabetes, and ischemic heart disease risk factors.

Objective : Exploring the changes in adiponectin, resistin and their ratio levels among healthy subjects and type 2 diabetes, with and without ischemic heart disease; and to study the relationship of these levels with some cardiovascular risk factors and their predictive potential for ischemic cardiac disease.

Methods : The study included 159 Syrian subjects (40 control participants, 60 type 2 diabetics, and 59 type 2 diabetics with ischemic cardiac disease.

Anthropometric measurements, insulin resistance and sensitivity, lipid profile components, and inflammation status, as well as adiponectin and resistin were evaluated in all participants using suitable methods.

Statistical tests were done using version 22.0 of SPSS, and a P-value of less than 0.05 was considered as statistically significant.

Results : The levels of adiponectin decreased, while the levels of both resistin and their ratio to adiponectin increased, in patients with type 2 diabetics compared to controls, and these changes were at greatest levels in type 2 diabetics with ischemic heart disease.

These changes were positively associated with the severity of cardiovascular risk factors in patients with ischemic heart disease.

Conclusion : These results suggest that the measurement of resistin and adiponectin and the ratio between their levels in patients with diabetes and ischemic heart disease can be important as useful biomarkers, predictive factors, and treatment targets for obesity and the associated insulin resistance, type 2 diabetes and ischemic heart disease.