تحضير تحاميل مهبلية من الفاردينافيل و تقييمها في المختبر

Abstract EN

The vagina is considered a potential route for delivering drugs to the uterus with minimizing side effects and increasing bioavailability.

Vardenafil is a type of 5-specific phosphodiesterase inhibitors, with low oral bioavailability about 15%.

Thus targeting drug delivery through vagina is considered perfect for drugs such as vardenafil.

The objective of this study is to formulate and evaluate vardenafil vaginal suppositories, to study the effect of different surfactants and additives on the drug release rate.

Suppositories containing 20 mg of vardenafil were prepared and characterized for weight variation, content uniformity, hardness, disintegration time.

The in vitro dissolution medium was also investigated.